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In the slowly progressive neurodegenerative disorders like Parkinson’s disease and Alzheimer’s disease very different neuronal populations undergo degenerative processes, although, the cascades of cellular events leading to death are supposed to be similar. We suggest that the complex pattern of degeneration in Parkinson’s disease depends on two processes, a ‘primary neurodegeneration’ that takes...
We studied the effects of experimental hemiparkinsonism upon sympathetic function in rat. The rats were divided into three groups: a group given intact control, one given lesioning with 6-hydroxydopamine (6-OHDA), and one given sham operation. One day after apomorphine testing following lesioning of the substantia nigra (SN) with 6-OHDA, heart rate (HR), mean arterial blood pressure (MAP), and electrocardiogram...
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