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Metaloproteinazy (MMP), ich tkankowe inhibitory (TIMP) i lipokalina neutrofilowa związana z żelatynazą (NGAL) mogą odgrywać zasadniczą rolę w progresji zmian miażdżycowych, ale dane dotyczące takich zależności w przewlekłej chorobie nerek (PChN) są skąpe.Celem pracy była ocena stężeń NGAL i wybranych metaloproteinaz u dzieci z PChN w okresie predializacyjnym w powiązaniu z markerami uszkodzenia śródbłonka...
Metalloproteinases are the proteolytic enzymes that digest components of the extracellular matrix in many physiological and pathological conditions. Their activity is regulated by their natural inhibitors: non-specific α2-macroglobulin and specific tissue inhibitors of metalloproteinases (TIMP). There are four TIMPs. TIMP-2 is the only enzyme that is expressed in constitutive manner and has the ability...
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