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Chronic hepatitis B (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). Most HCCs complicate the evolution of an active or inactive cirrhosis. However, some tumors occur on livers with minimal histological changes; the prevalence of such cases varies from one geographical region to the other, being much higher in the Southern half of Africa (around 40% of HCCs) than in Asia,...
One of the most characteristic features of biological molecular networks is that the network structure itself changes, depending on the cellular environment. Indeed, activated molecules show a variety of responses to distinctive cell conditions, and subsequently the network structures of active molecules also change. Here we present an approach to trace the network structure changes by using the graphical...
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