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Alzheimers disease (AD) is a complex neurodegenerative dementing illness. Over the past few years, however, remarkable advances have taken place in understanding both the genetic and molecular biology with the intracellular processing of amyloid and tau and the changes leading to the pathologic formation of extracellular amyloid plaques and the intraneuronal aggregation of hyperphosphorylated tau...
Autoantibodies against amyloid β (Aβ) peptide found in patients with Alzheimer’s disease (AD) also occur naturally in the general population independently of the cognitive status. We compared serum Aβ 1–42 autoantibody levels (Aβ 1–42 -AL) of 96 AD patients and 30 healthy elderly control subjects (HC), assessing their diagnostic value for AD with a newly developed immunoprecipitation...
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