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The present work describes the protective effects of the crude Northeast Portuguese propolis enriched phenolic extract against staurosporine (STS) and hydrogen peroxide (H 2 O 2 )-induced neurotoxicity. These two stress inducers act through various pathways, including the production of reactive oxygen species (ROS) and the induction of apoptosis through caspases activation. STS (25...
Apoptosis is a form of cell death crucial for normal development and tissue homeostasis. Its typical features include chromatin changes, nuclear breakdown, plasma membrane blebbing and splitting of cellular content into apoptotic bodies, that progressively undergo phagocytosis.Apoptosis is considered essential for skeletal muscle development, where defective cells are deleted during differentiation...
AF5 neural cells derived from fetal rat mesencephalic tissue were immortalized with a truncated SV40 LT vector lacking the p53-inactivating domain to maintain long-term cultures with a p53-responsive phenotype. This study examined p53 function in producing programmed cell death in propagating AF5 neural cells after exposure to hydrogen peroxide (H 2 O 2 ) and the kinase inhibitor staurosporine...
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