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The lining of the uterus and cervix might be injured by a variety of oxidation products of Cu in a Cu-IUD, including cuprous ions, dissolved and precipitated cupric ions, and reactive oxygen species such as superoxide radicals, hydrogen peroxide, and hydroxyl radicals. In this study, the human amnious WISH cell line was employed as a model of uterine cells in the presence of copper. The cell viability...
The antioxidant propyl gallate (PG) induced single strand breaks in PM2 DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. In combination with 100 μM CuCl 2 , extensive double strand breakage was also observed. Neither PG alone nor CuCl 2 showed any strand breaking properties. DNA strand breakage was inhibited by addition of...
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