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A key step in the development of an adaptive immune response to vaccines is the binding of peptides to molecules of the Major Histocompatibility Complex (MHC) for presentation to T lymphocytes, which are thereby activated. Several algorithms have been proposed for such binding predictions, but are limited to a small number of MHC molecules and present imperfect prediction power. We are undertaking...
Many methods for classification and gene selection with microarray data have been developed. These methods usually give a ranking of genes. Evaluating the statistical significance of the gene ranking is important for understanding the results and for further biological investigations, but this question has not been well addressed for machine learning methods in existing works. Here, we address this...
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