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Although bone–tissue stiffness is closely related to the degree to which bone has been mineralized, other determinants are yet to be identified. We, therefore, examined the extent to which the mineralization degree, collagen, and its cross-links are related to bone–tissue stiffness.A total of 50 cancellous and cortical bone samples were derived from the right mandibular condyles of five young and...
Examine effects of insulin-like growth factor 1 (IGF1), transforming growth factor β2 (TGFβ2) and fibroblast growth factor 2 (FGF2) on proteoglycan and collagen network and biomechanical properties of the newly formed cartilage matrix.Bovine articular chondrocytes were cultured in alginate beads for 3 weeks with or without FGF2, TGFβ2 or IGF1 in the presence of 10% FCS. Proteoglycan content, collagen...
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