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The self-assembly of asymmetric di- and triblock block copolymers based on chemically complementary poly(acrylic acid) and (methoxy)poly(ethylene oxide) or polyacrilamide blocks into micelle structures are developed in acidic aqueous solutions by hydrophobic interactions between non-polar bound segments of the copolymer blocks. Peculiarities of the micellization processes, morphology, size and stability...
Drug delivery system (DDS) is the process of administering a drug-loaded composite to achieve a therapeutic effect in vitro or in vivo. In this paper, we present the fabrication of imiquimod-poly(ε-caprolactone) (PCL) fibre meshes for the melanoma therapy application. The fabrication was based on the electrospinning technique and NIH-3T3 fibroblast cells were cultured on electrospun fibre meshes to...
Since there have been many difficulties in clinical administration of anticancer drugs due to their poor solubility & targeting, development of new biodegradable Nano-carriers can provide good solutions to overcome the most of recent problems to obtain a better controlled release and targeted delivery of drugs with better efficiency and less side-effects. Acidic pH is regarded as a phenotypic...
The ElectroNanospraytrade process (Nanocopoeia, Inc) transforms drugs and polymers into many nanoscale material states including powders, liquids, encapsulated particles, and coatings. This enabling technology platform allows application of polymers and drugs to the surface of medical devices such as coronary stents in a single-stage process. Modification of ElectroNanospray process parameters resulted...
Biodegradable polymer polycaprolactone (PCL; Mw~100,000) fiber mats containing shikonin from the plant Lithospermumerythrorhizon, widely known for its wound healing, anti-tumor, antioxidant, and anti-inflammatory properties, were prepared via electrospinning method. Incorporation of shikonin in the neat PCL solution did not affect the morphology of the resulting fibers, as both the neat and the shikonin-loaded...
To mimic natural extracellular matrix architecture, the poly (L-lactic acid) (PLLA) scaffolds loading icariin and icariin-2-hydroxypropyl-beta-cyclodextrin inclusion complex were prepared via phase separation, solvent replacement and freeze-drying. The morphologies of PLLA scaffolds were visualized with scanning electron microscopy, the icariin concentration and drug release in vitro were determined...
In the present study, Eudragit L100 was successfully spun into ultrafine fibers using electrospinning process. The electrospinnability of Eudragit L100 in DMAc, ethanol, methanol, and the mixed solvents of DMAc and methanol with different ratios were examined. The morphologies of the as-spun Eudragit L100 fiber mats were observed using SEM. The results demonstrated that Eudragit L100 was able to be...
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