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Acidity within the extracellular milieu is a hallmark of cancer. There is a current need for fast, high spatial resolution pH imaging techniques for clinical evaluation of cancers, including gliomas. Chemical exchange saturation transfer (CEST) MRI targeting fast‐exchanging amine protons can be used to obtain high‐resolution pH‐weighted images, but conventional CEST acquisition strategies are slow...
Purpose
The aim of this study was to develop a technique for rapid collection of chemical exchange saturation transfer images with the saturation varied to modulate signal loss transfer and enhance contrast.
Methods
Multi‐echo Length and Offset VARied Saturation (MeLOVARS) divides the saturation pulse of length Tsat into N = 3–8 submodules, each consisting of a saturation pulse with length of T...
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