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The role of homeobox-containing genes in embryogenesis and organogenesis is well documented. Also, a sizeable body of evidence has accumulated and supports the fact that homeobox genes, when dysregulated, are involved in tumorigenesis. However, the precise mechanisms of homeobox gene functions are largely unknown. The mammary gland, in which most maturation occurs postnatally, provides an ideal model...
Since serum is a source of hormones, growth factors, cytokines and antioxidants being a survival factor for cell culture its withdrawal from the culture medium induces apoptosis in a variety of cell types. In the present study the effect of FCS - deprivation on Bcl-2 protein level, Bax transcript and apoptosis of L1210 leukaemic cells was examined. The possibility of the existence of cellular origin...
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