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Cardiac output (CO) is a cardinal parameter of cardiovascular system, and a fundamental determinant of global oxygen delivery. Also, Left ventricular ejection fraction (EF) which is the ratio of the stroke volume to the end-diastolic volume of the left ventricle, is widely recognized as one of the most clinically significant indices of cardiac function. Current methods for measuring both of them are...
Obtaining vital signs non-invasively and in a wearable manner is essential for personal health monitoring. We propose the site behind the ear as a location for an integrated wearable vital signs monitor. This location is ideal for both physiological and mechanical reasons. Physiologically, the reflectance photoplethysmograph (PPG) signal behind the ear shows similar signal quality when compared to...
Heart failure is simulated using a cardiovascular system model with embedded autonomic nervous regulation and renal blood volume adjustment. The main cardiovascular parameters under heart failure are set as reducing the left ventricular myocardial maximum elasticity by 50%, increasing sympathetic nerve activity by 20% and decreasing vagus nerve activity by 80%, increasing peripheral resistance by...
Implantable radio-telemetry methodology, allowing for continuous recording of pulmonary haemodynamics, has previously been used to assess effects of therapy on development and treatment of pulmonary hypertension. In the original procedure, rats were subjected to invasive thoracic surgery, which imposes significant stress that may disturb critical aspects of the cardiovascular system and delay recovery...
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