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In this invited session, we would like to address the impact of bionic neuromodulation on cardiovascular diseases. It has been well established that cardiovascular dysregulation plays major roles in the pathogenesis of cardiovascular diseases. This is the reason why most drugs currently used in cardiology have significant pharmacological effects on the cardiovascular regulatory system. Since the ultimate...
Aim: To investigate the potential effects of taurine on calcium ion concentration and ATPase on cell membrane of diastole heart failure rat model. Method: Mouse models of diastole heart failure were made by the incomplete ligation of abdominal aorta. Forty Wistar heart failure rats were divided randomly into four groups, with 10 for each group (n=10). Heart failure rats were treated according to different...
Development of drugs requires electrophysiological studies of small animals like mice, rats or guinea pigs. Electrocardiography (ECG) of hirsute animals is time-consuming. We have developed a micro magnetometer array with a 9-channel superconducting quantum interference device (SQUID) with a 2.5-mm diameter pickup-coil for noncontacting measurement of magnetocardiograms (MCGs) in small animals. The...
Lidocaine is a class I antiarrhytmic drug that blocks the sodium channels. This drug is a tertiary amine and exists as an uncharged free amine and cationic protonated form at physiologic pH. Experimental data have shown that the rate of development and recovery of block is slowed at low pH. In this work, a mathematical model of lidocaine effects has been developed. This model has been incorporated...
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