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The authors studied the application of photosensitization-reaction-induced cytotoxicity to establish electrical blockade of myocardial tissue. This photosensitization-reaction-induced cytotoxicity, i.e., photodynamic therapy (PDT) was performed with chlorine photosensitizer, talaporfin sodium, and a red (670 nm) diode laser. The cytotoxicity on rat cardiac myocytes and the electrical blockade by PDT...
Lidocaine is a class I antiarrhytmic drug that blocks the sodium channels. This drug is a tertiary amine and exists as an uncharged free amine and cationic protonated form at physiologic pH. Experimental data have shown that the rate of development and recovery of block is slowed at low pH. In this work, a mathematical model of lidocaine effects has been developed. This model has been incorporated...
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