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The aim of this study was to examine the involvement of the dorsal raphe nucleus (DRN) presynaptic serotonergic 5-HT 1A autoreceptors on sleep and waking parameters, in particular rapid eye movement (REM) sleep. In a previous study, the systemic administration of the selective 5-HT 1A receptor antagonist p-MPPI reduced REM sleep in a dose-dependent manner suggesting a blockade...
Previous studies have shown that a wide range of sedative/hypnotic agents, including ethanol, induce sleep when microinjected into the medial preoptic area (MPA) of the anterior hypothalamus. The mechanism by which ethanol acts at this site to induce sleep has not been clear, though possibilities include alterations of chloride channel function in the GABA A -benzodiazepine receptor complex,...
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