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Vestibular dysfunction has been shown to cause spatial memory impairment. Neurophysiological studies indicate that bilateral vestibular loss (BVL), in particular, is associated with an impairment of the response of hippocampal place cells and theta rhythm. However, the specific neural pathways through which vestibular information reaches the hippocampus are yet to be fully elucidated. The aim of the...
Although the mechanism responsible for cognitive deficits or a depressive state in stress-related neuropsychiatric disorders has not been fully elucidated, dopaminergic or serotonergic dysfunction in the prefrontal cortex (PFC) is thought to be involved. In rats, the mesoprefrontal dopaminergic system, in particular, is activated in response to acute stress, whereas chronic stress reduces dopaminergic...
Although the mechanism responsible for cognitive deficits or a depressive state in stress-related neuropsychiatric disorders has not been fully elucidated, dopaminergic or serotonergic dysfunction in the prefrontal cortex (PFC) is thought to be involved. In rats, the mesoprefrontal dopaminergic system, in particular, is activated in response to acute stress, whereas chronic stress reduces dopaminergic...
Rationale The hypofunction of NMDA receptors in the prefrontal cortex (PFC) has been suggested to produce corticolimbic hyperactivity through the reduction of cortical GABA transmission. Objectives The present study investigates the effects of injections of the NMDA antagonist 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP) into the PFC on (1) the release of dopamine and/or acetylcholine...
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