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Rationale. In schizophrenia, attentional disturbance is a core feature which may not only accompany the disorder, but may precede the onset of psychiatric symptoms. Objectives. The five-choice serial reaction time task (5CSRTT) is a test of visuo-spatial attention that has been used extensively in rats for measuring the effects of systemic and central neurochemical manipulations on various aspects...
Rationale. Degeneration of the cholinergic magnocellular neurons in the basal forebrain and their cortical projections is a major feature of the neuropathology of Alzheimers disease (AD). In addition to memory dysfunction, attentional functions are also impaired in AD. Objective. We investigated the extent to which the cholinesterase inhibitor donepezil reversed the attentional performance deficit...
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