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The effect of difluoromethylornithine (DFMO), an irrevesible inhibitor of ornithine decarboxylase (ODC), the rate limiting enzyme of polyamine biosynthesis, and its combined action with GM1 ganglioside, was studied on the GFAP content in a model of remote astrogliosis evoked in the hippocampus by latral fimbria transection.DFMO markedly suppressed hipocampal gliosis as measured by GFAP immunoblotting...
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