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Gastric cancer remains one of the most common forms of cancer worldwide. With current diagnostic and therapeutic approaches the prognosis of gastric cancer is very poor. Similar to other solid cancers, gastric cancer is a complex disease resulting from combinatorial interactions among diverse factors including environmental, host-genetic and molecular mechanisms. Gastric cancers arise in part because...
Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are mature B-cell lymphoid neoplasms with an identical immunophenotype that are currently thought to be very closely related if not identical. As a result, the current World Health Organization classification of hematolymphoid diseases has designated this disease as chronic lymphocytic leukemia/small lymphocytic lymphoma. Patients...
Cancer results from the stepwise accumulation of genetic alterations within a cell. These alterations lead to abnormal proliferation and clonal expansion, and ultimately to invasion of surrounding tissues and metastasis to distant sites. Genetic abnormalities providing a selective advantage are maintained and ultimately become dominant within the population. The accumulation of genetic abnormalities,...
Cancer is a complex disease in which cells display uncontrollable growth and invade adjacent tissues, sometimes spreading to other locations in the body. Because of the complexity of tumors, they are often difficult to treat using conventional means such as radiation and chemotherapy. microRNAs (miRNAs) are a class of small noncoding RNAs that regulate the expression of several target proteins. They...
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