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This chapter describes recent developments in the analysis of kappa opioid receptor (KOR) function at a molecular, cellular and systems level within the central and peripheral nervous system. A combination of neuroanatomical, electrophysiological and behavioral techniques have been used to probe the functional consequences of KOR activation in the brain and spinal cord in both normal and pathological...
κ Opioid receptors were first proposed by the author based on the actions of benzomorphans, such as ketocyclazocine. κ receptors are involved with a wide range of actions, providing novel targets for drug development. This chapter will explore the pharmacology of κ receptors in a range of behavioral effects and their functions at the biological level.
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