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Administering relaxin to conscious rats and humans elicits systemic and renal vasodilation. The molecular mechanisms vary according to the duration of relaxin exposure—so-called “rapid” (within minutes) or “sustained” (hours to days) vasodilatory responses—both being endothelium-dependent. Rapid responses are mediated by Gαi/o protein coupling to phosphoinositol-3 kinase/Akt (protein kinase B)–dependent...
Fluctuations in vascular calibre, a phenomenon known as vasomotion, are ubiquitous in the microcirculation and represent emergent behaviour that involves synchronisation of Ca2+ oscillations in individual vascular cells. Ideally, coordinated interactions between locally generated vasomotion and neuro-humoral control mechanisms will allow optimal sensing of flow and pressure within vascular networks...
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