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The direct catalytic asymmetric hydrogenation of pyridines for the synthesis of piperidines remains a challenge. Herein, we report a one‐pot asymmetric hydrogenation of pyridines with subsequent N‐alkylation using a traceless Brønsted acid activation strategy. Catalyzed by an iridium‐BINAP complex, the substrates undergo ketone reduction, cyclization and pyridine hydrogenation in sequence to form...
The direct catalytic asymmetric hydrogenation of pyridines for the synthesis of piperidines remains a challenge. Herein, we report a one‐pot asymmetric hydrogenation of pyridines with subsequent N‐alkylation using a traceless Brønsted acid activation strategy. Catalyzed by an iridium‐BINAP complex, the substrates undergo ketone reduction, cyclization and pyridine hydrogenation in sequence to form...