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Proteinase 3 (PR3) is a 29-kDa serine proteinase, with homology to human leukocyte elastase (HLE) and cathepsin G (Cat G), secreted from activated neutrophils. It was found that PR3, but not HLE and Cat G, activated the oral epithelial cells to produce interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 and to express intracellular adhesion molecule (ICAM)-1. Oral epithelial cells express...
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