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The role of Sildenafil was found in the potential weight gain of the foetus in pregnant women with intrauterine growth retardation (IUGR). Sildenafil acted by inhibiting phosphodiesterase type 5 (PDE5), which was an important enzyme responsible for the degradation of Cyclic guanosine monophosphate (cGMP), resulting in prolongation of action of cGMP and therefore prolonged smooth muscle relaxation...
The role of Sildenafil was found in the potential weight gain of the foetus in pregnant women with intrauterine growth retardation (IUGR). Sildenafil acted by inhibiting phosphodiesterase type 5 (PDE5), which was an important enzyme responsible for the degradation of Cyclic guanosine monophosphate (cGMP), resulting in prolongation of action of cGMP and therefore prolonged smooth muscle relaxation...