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A major challenge in the elucidation of brain neurotransmitter events in vivo in the laboratory and in the operating room has been the development of methods to record neurotransmitters in the CNS on a second-by-second time scale. Microdialysis methods have been widely employed but are limited due to their inherent slow sampling rates (1-20 min) and poor exchange (~10-20%) of neurotransmitters. We...
The prefrontal cortex and basal ganglia are deeply implicated in working memory. Both structures are subject to dopaminergic neuromodulation in a way that exerts a critical influence on the proper operation of working memory. We present a novel network model to elucidate the role of phasic dopamine in the interaction of these two structures in initiating and maintaining mnemonic activity. We argue...
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