Search results
IUBMB Life > 72 > 5 > 1001 - 1011
EPMA Journal > 2019 > 10 > 2 > 153-172
BMC Bioinformatics > 2019 > 20 > 7 > 97-107
Annals of the New York Academy of Sciences > 1333 > 1 > 1 - 32
article
Intestinal ischemia–reperfusion injury (IIR) is a life‐threatening abdominal emergency. Compared to traditional steady‐state works, we profiled the blood of rats over 72 hr (15 time points) and examined dynamic changes in molecular pathways during IIR. Using a series of methods designed for dynamic datasets analysis (batch effects corrections, metabolomics data reduction, and different features selection),...
article
Relevance Molecular network changes are the hallmark of the pathogenesis of ovarian cancers (OCs). Network-based biomarkers benefit for the effective treatment of OC. Purpose This study sought to identify key pathway–network alterations and network-based biomarkers for clarification of molecular mechanisms and treatment of OCs. Methods Ingenuity Pathway Analysis (IPA) platform was used to mine...
article
Background The mechanism of many complex diseases has not been detected accurately in terms of their stage evolution. Previous studies mainly focus on the identification of associations between genes and individual diseases, but less is known about their associations with specific disease stages. Exploring biological modules through different disease stages could provide valuable knowledge to genomic...
article
Cumulative findings from many research groups have identified new signaling mechanisms associated with head and neck cancers. We summarize these findings, including discussion of aberrant NOTCH, PI3K, STAT3, immune recognition, oxidative pathway, and regulation of cell cycle and cell death. The genomic landscape of head and neck cancers has been shown to differ depending on human papillomavirus (HPV)...
chapter
Drugs and biological experiments are designed to affect a particular target gene or pathway. However, they might inadvertently activate other pathways and cause side effects. Because of the existence of complex cellular mechanisms responding to stimuli, it is difficult to detect the presence of such side effects. Therefore, identification of pathways that function together under identical conditions...
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