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article

Pain in autoimmune disorders

Katherine A. Mifflin, Bradley J. Kerr

Journal of Neuroscience Research > 95 > 6 > 1282 - 1294

Most autoimmune diseases are associated with pathological pain development. Autoimmune diseases with pathological pain include complex regional pain syndrome, rheumatoid arthritis, and Guillian‐Barré syndrome to name a few. The present Review explores research linking the immune system to the development of pathological pain in autoimmune diseases. Pathological pain has been linked to T‐cell activation...

article

Src/p38 MAPK pathway in spinal microglia is involved in mechanical allodynia induced by peri-sciatic administration of recombinant rat TNF-α

Yu-Ying Li, Xu-Hong Wei, Zhen-He Lu, Jin-Sheng Chen, more

Brain Research Bulletin > 2013 > 96 > Complete > 54-61

Our previous work has shown that peri-sciatic administration of recombinant rat TNF-α (rrTNF) induces mechanical allodynia and up-regulation of TNF-α in the spinal dorsal horn of rats; however, the underlying mechanisms remain unknown. In the current study, we found that the levels of phosphorylated Src-family kinases (p-SFKs) and phosphorylated p38 mitogen-activated protein kinase (p-p38 MAPK) were...

article

Multiple mechanisms of microglia: A gatekeeper's contribution to pain states

Manuel B. Graeber, MacDonald J. Christie

Experimental Neurology > 2012 > 234 > 2 > 255-261

Microglia are gatekeepers in the CNS for a wide range of pathological stimuli and they blow the whistle when things go wrong. Collectively, microglia form a CNS tissue alarm system (Kreutzberg's “sensor of pathology”), and their involvement in physiological pain is in line with this function. However, pathological neuropathic pain is characterized by microglial activation that is unwanted and considered...

article

Peripheral and Central Mechanisms of Trigeminal Neuropathic and Inflammatory Pain

Mamoru Takeda, Shigeji Matsumoto, Barry J. Sessle, Masamichi Shinoda, more

Journal of Oral Biosciences > 2011 > 53 > 4 > 318-329

While physiological pain (nociceptive pain) has a protective role in warning of potential tissue damage in response to a variety of noxious stimuli, pathological pain (neuropathic and inflammatory pain) serves no such meaningful purpose. Injury/inflammation in the peripheral tissue that innervates the trigeminal nerve may also alter the properties of trigeminal somatic sensory pathways, causing behavioral...

article

Using the intact hand for objective assessment of phantom hand-perception

Masahiko Sumitani, Arito Yozu, Toshiya Tomioka, Yoshitsugu Yamada, more

European Journal of Pain > 2010 > 14 > 3 > 261-265

After amputation, most patients experience a phenomenon known as a phantom limb (PL). A variety of PL experiences appear to be associated with neural plasticity within the CNS. However, due to the subjective nature of PL experiences, there was no definitive way to reliably assess PL experiences other than using patients’ direct reports. Here, we were able to obtain patients’ indirect responses to...

article

Antinociceptive effects of systemic lidocaine: Involvement of the spinal glycinergic system

Uta Muth-Selbach, Henning Hermanns, Jens Ulrich Stegmann, Kathrin Kollosche, more

European Journal of Pharmacology > 2009 > 613 > 1-3 > 68-73

Beside their action on voltage-gated Na ⁺ channels, local anesthetics are known to exert a variety of effects via alternative mechanisms. The antinociceptive effect of lidocaine is well documented, yet the exact mechanism is not fully understood. Whether glycinergic mechanisms, which play a pivotal role in pain modulation, are involved in lidocaine-induced antinociception is hitherto unclear...

article

Spinal glial activation contributes to pathological pain states

Hong Cao, Yu-Qiu Zhang

Neuroscience and Biobehavioral Reviews > 2008 > 32 > 5 > 972-983

Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of study on the neuronal processing of pain, mechanisms underlying the creation and maintenance of enhanced pain states after injury or inflammation remain far from clear. In the last decade, however, the discovery that glial activation amplifies pain has challenged classic neuronal views of “pain”. This review...

article

Expanding use of botulinum toxin

Roongroj Bhidayasiri, Daniel D. Truong

Journal of the Neurological Sciences > 2005 > 235 > 1-2 > 1-9

Botulinum toxin type A (BTX-A) is best known to neurologists as a treatment for neuromuscular conditions such as dystonias and spasticity and has recently been publicized for the management of facial wrinkles. The property that makes botulinum toxin type A useful for these various conditions is the inhibition of acetylcholine release at the neuromuscular junction. Although botulinum toxin types A...

article

Neuronal Plasticity and Signal Transduction in Nociceptive Neurons: Implications for the Initiation and Maintenance of Pathological Pain

Ru-Rong Ji, Clifford J. Woolf

Neurobiology of Disease > 2001 > 8 > 1 > 1-10

Pathological pain, consisting of tissue injury-induced inflammatory and nerve injury-induced neuropathic pain, is an expression of neuronal plasticity. One component of this is that the afferent input generated by injury and intense noxious stimuli triggers an increased excitability of nociceptive neurons in the spinal cord. This central sensitization is an activity-dependent functional plasticity...

article

Two distinctive antinociceptive systems in rats with pathological pain

J. Mao, D.D. Price, J. Lu, L. Keniston, more

Neuroscience Letters > 2000 > 280 > 1 > 13-16

A common obstacle in clinical management of pathological pain is the poor response to opioid analgesics. We now report that Δ ⁹ -tetrahydrocannabinol (Δ ⁹ -THC)-induced antinociception remained effective in rats with pathological pain. The selective central cannabinoid receptor antagonist SR141716A, but not the generic opioid receptor antagonist naloxone, blocked the Δ ⁹ -THC...

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Keywords

PATHOLOGICAL PAIN (10)
MICROGLIA (3)
ALLODYNIA (1)
ANTINOCICEPTION (1)
ASTROCYTES (1)
ASTROGLIA (1)
AUTOANTIBODIES (1)
AUTOIMMUNE DISEASE (1)
BOTULINUM TOXIN (1)
CANNABINOIDS (1)
CENTRAL SENSITIZATION (1)
CHRONIC CONSTRICTION INJURY (1)
CNS AUTONOMOUS AND SPECIFIC MECHANISMS OF MICROGLIAL ACTIVATION (1)
COMPLEX (1)
CRPS (1)
DEAFFERENTATION (1)
DISEASED MICROGLIA (1)
DROOLING (1)
FORMALIN TEST (1)
GLIAL ACTIVATION (1)
GLYCINE (1)
HAND-SIZE PERCEPTION (1)
HEADACHE (1)
HYPERALGESIA (1)
HYPERHIDROSIS (1)
IMMUNE SYSTEM (1)
INFLAMMATION (1)
LIDOCAINE (1)
MAP KINASE (1)
MORPHINE (1)
NEURONAL PLASTICITY (1)
NOCICEPTION (1)
NOCICEPTIVE NEURONS (1)
NORMAL PAIN (1)
P38 MITOGEN-ACTIVATED PROTEIN KINASE (1)
PHANTOM LIMB (1)
PRIMARY SENSORY NEURONS (1)
PROINFLAMMATORY CYTOKINES (1)
REGIONAL PAIN SYNDROME (1)
RHEUMATOID ARTHRITIS (1)
SATELLITE GLIAL CELLS (1)
SIALORRHEA (1)
SIGNAL TRANSDUCTION (1)
SJÖRDEN'S SYNDROME (1)
SPINAL CORD (1)
SRC-FAMILY KINASES (1)
T CELLS (1)
TH17 (1)
TNF-Α (1)
TRANSCRIPTION (1)
TRIGEMINAL GANGLION NEURONS (1)
TRIGEMINAL SPINAL NUCLEUS CAUDALIS (1)
VGCC (1)
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Elsevier (9)
Wiley (1)

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