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Injectable hydrogels find extensive application in the treatment of diabetic wound healing. However, traditional bulk hydrogels are significantly limited due to their nano‐porous structure, which obstructs cell migration and tissue infiltration. Moreover, regulating inflammation and matrix metalloproteinase ‐9 (MMP‐9) expression in diabetic wounds is crucial for enhancing wound healing. This study...
A novel biodegradable sodium poly(aspartic acid) (PASP) hydrogel with microporous structure was manufactured using electrospun polysuccinimide (PSI) nanofibers. PSI is the intermediate of sodium PASP and could be electospun into nanofibers easily. Firstly, PSI nanofibers were prepared from PSI/N, N-dimethylformamide solution. Then the PSI nanofibrous mats were crosslinked and hydrolyzed to obtain...
A series of novel thermo- and pH-sensitive (NP10-AA TPS) hydrogels and microporous (NP10-AA MP) hydrogels, inducing by polyoxyethylene (10) nonyl phenyl ether (NP-10) aqueous two-phase system, was designed and fabricated with acrylic acid (AA) as the monomer for the first time. The resultant NP10-AA TPS hydrogel, compared with the traditional TPS hydrogel, was more advanced in both of the high swelling...
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