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article

HPV DNA genotyping and methylation of gene p16INK4A in cervical LSIL

Filomena Aste Silveira, Gutemberg Almeida, Yara Furtado, Kátia S. Silva, more

Experimental and Molecular Pathology > 2015 > 98 > 2 > 308-311

Background: DNA methylation is the most important epigenetic change involved in the control of gene expression in human cells. Methylation of the p16 ^I ^N ^K ⁴ ^a gene occurs early in the development of cervical cancer. Low-grade squamous intraepithelial lesions (LSILs) are prevalent, and their behavior is variable. Objective: To identify the HPV DNA type, detect the methylation...

article

Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile

Dawit Melak, Catterina Ferreccio, David Kalman, Roxana Parra, more

Toxicology and Applied Pharmacology > 2014 > 274 > 2 > 225-231

In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although this process is not complete in most people. The trivalent form of MMA is highly toxic in vitro and previous studies have identified associations between the proportion of urinary arsenic as MMA (%MMA) and several arsenic-related diseases. To date, however, relatively little is known...

article

Amino Acids as biomarkers in the SOD1G93A mouse model of ALS

Monica Bame, Robert E. Grier, Richard Needleman, William S.A. Brusilow, more

BBA - Molecular Basis of Disease > 2014 > 1842 > 1 > 79-87

The development of therapies for Amyotrophic Lateral Sclerosis (ALS) has been hindered by the lack of biomarkers for both identifying early disease and for monitoring the effectiveness of drugs. The identification of ALS biomarkers in presymptomatic individuals might also provide clues to the earliest biochemical correlates of the disease. Previous attempts to use plasma metabolites as biomarkers...

article

Heterogeneous catalysts based on B/P/O for the monoetherification of 1,2-dihydroxybenzene in the gas phase

Lorenzo Calzolari, Fabrizio Cavani, Tiziana Monti

Comptes Rendus de l'Academie des Sciences Series IIC Chemistry > 2000 > 3 > 6 > 533 - 539

Boron-phosphorus mixed oxides were tested as heterogeneous catalysts for the gas-phase etherification of catechol (1,2-dihydroxybenzene) with methanol, aimed at the production of guaiacol (1-methoxyphenol). This reaction represents an alternative to the etherification processes which makes use of homogeneous catalysts in the liquid phase. The activity of the catalysts was found to depend considerably...

article

Protein Modifications During Early Embryo Development

Le Zhang, Yanbing Zhang, Hailong Sun

American Journal of Reproductive Immunology > 92 > 4 > n/a - n/a

Background Infertility is a global reproductive health burden. Assisted reproductive technologies (ARTs) have been widely used to help patients become pregnant. Few embryos develop to the blastocyst stage with ARTs, leading to relatively low live birth rates. Protein modifications play crucial roles in nearly every aspect of cell biology, including reproductive processes. The aim of this study was...

article

Fluorescence in situ hybridization‐negative intra‐articular myxoid liposarcoma with complex rearrangements involving EWSR1::DDIT3 detected using nanopore sequencing

Naohiro Makise, Jason Lin, Hajime Kageyama, Naoki Takeda, more

Pathology International > 74 > 10 > 604 - 610

Myxoid liposarcoma (MLPS) is a rare sarcoma, typically arising in deep soft tissues during the fourth to fifth decades of life. Histologically, MLPS is composed of uniform oval cells within a background of myxoid stroma and chicken‐wire capillaries. Genetically, MLPS is characterized by the FUS/EWSR1::DDIT3 fusion gene, which generally results from balanced interchromosomal translocation and is detectable...

article

Downregulation of C1R promotes hepatocellular carcinoma development by activating HIF‐1α‐regulated glycolysis

Yuying Ma, Yuehua Wang, Peng Tuo, Zhongji Meng, more

Molecular Carcinogenesis > 63 > 11 > 2237 - 2253

C1R has been identified to have a distinct function in cutaneous squamous cell carcinoma that goes beyond its role in the complement system. However, it is currently unknown whether C1R is involved in the progression of hepatocellular carcinoma (HCC). HCC tissues were used to examine C1R expression in relation to clinical and pathological factors. Malignant characteristics of HCC cells were assessed...

article

Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions

Joanna Cyrta, Josephine K Dermawan, Arnault Tauziède‐Espariat, Ting Liu, more

The Journal of Pathology > 264 > 3 > 305 - 317

CREB gene family (ATF1, CREB1, CREM) fusions with either EWSR1 or FUS gene partners drive the pathogenesis of a wide range of neoplasms, including various soft tissue tumors, intracranial myxoid mesenchymal tumors (IMMTs), hyalinizing clear cell carcinoma (HCCC), and rare mesotheliomas. Recently, a SMARCA2::CREM fusion was reported in one case each of IMMT and HCCC. In this study, we expand the clinicopathologic...

article

Deep learning can predict subgenome dominance in ancient but not in neo/synthetic polyploidized genomes

Zhongwei Guo, Kang Zhang, Chengcheng Cai, Xing Li, more

The Plant Journal > 120 > 1 > 174 - 186

Deep learning offers new approaches to investigate the mechanisms underlying complex biological phenomena, such as subgenome dominance. Subgenome dominance refers to the dominant expression and/or biased fractionation of genes in one subgenome of allopolyploids, which has shaped the evolution of a large group of plants. However, the underlying cause of subgenome dominance remains elusive. Here, we...

article

Diagnostic value for methylation in cervical cancer based on a small‐molecule fluorescent probe targeting DNMT1

Baohua Yang, Chao Xu, Hang Li, Xiuxiang Zhu, more

Skin Research and Technology > 30 > 9 > n/a - n/a

Background Value analysis of a small‐molecule fluorescent probe for methylation detection in different cervical lesions. Materials and Methods (1) The grayscale values of distinct lesion tissues were remarkably distinct among the four groups (p < 0.05). The comparison of the grayscale value between the two groups showed that the CA group noticeably exceeded the LSIL and cervicitis groups, and...

article

A methylation‐related lncRNA‐based prediction model in lung adenocarcinomas

Kun Yang, Hao Liu, Jun Hai Li

The Clinical Respiratory Journal > 18 > 8 > n/a - n/a

Background The collaboration between methylation and the lung adenocarcinoma (LUAD) occurrence and development is closes. Long noncoding RNA (lncRNA), as a regulatory factor of various biological functions, can be used for cancer diagnosis. Our study aimed to construct a robust methylation‐related lncRNA signature of LUAD. Methods In the Cancer Genome Atlas (TCGA) dataset, we download the RNA expression...

article

Betaine activates the Nrf2‐Keap1‐ARE pathway by increasing the methylation level of Keap1 DNA promoter

Mengmeng Zhang, Tianchui Wang, Sixian Ou, Yucong Zou, more

International Journal of Food Science & Technology > 59 > 9 > 6231 - 6242

Betaine is a natural antioxidant lacking the ability to scavenge free radicals. Although it has been shown to exert antioxidant function by enhancing the expression of antioxidant enzymes, its mechanism has not yet been elucidated. This study explored the role and mechanism of the transcription factor NF‐E2‐associated factor 2 (Nrf2)‐Kelch‐like epichlorohydrin‐associated Protein 1 (Keap1) antioxidant...

article

An RRM domain protein SOE suppresses transgene silencing in rice

Rui Zhao, Wen‐Ai Wu, Yi‐Hua Huang, Xin‐Kai Li, more

New Phytologist > 243 > 5 > 1724 - 1741

Gene expression is regulated at multiple levels, including RNA processing and DNA methylation/demethylation. How these regulations are controlled remains unclear. Here, through analysis of a suppressor for the OsEIN2 over‐expressor, we identified an RNA recognition motif protein SUPPRESSOR OF EIN2 (SOE). SOE is localized in nuclear speckles and interacts with several components of the spliceosome...

article

Single generation epigenetic change in captivity and reinforcement in subsequent generations in a delta smelt (Hypomesus transpacificus) conservation hatchery

Ensieh Habibi, Michael R. Miller, Andrea Schreier, Matthew A. Campbell, more

Molecular Ecology > 33 > 15 > n/a - n/a

A refugial population of the endangered delta smelt (Hypomesus transpacificus) has been maintained at the Fish Conservation and Culture Laboratory (FCCL) at UC Davis since 2008. Despite intense genetic management, fitness differences between wild and cultured fish have been observed at the FCCL. To investigate the molecular underpinnings of hatchery domestication, we used whole‐genome bisulfite sequencing...

article

PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas

Tamara Cubiella, Lucía Celada, Jaime San‐Juan‐Guardado, Raúl Rodríguez‐Aguilar, more

The Journal of Pathology > 263 > 4-5 > 418 - 428

Neuroendocrine neoplasms (NENs) encompass tumors arising from neuroendocrine cells in various organs, including the gastrointestinal tract, pancreas, adrenal gland, and paraganglia. Despite advancements, accurately predicting the aggressiveness of gastroenteropancreatic (GEP) NENs based solely on pathological data remains challenging, thereby limiting optimal clinical management. Our previous research...

article

Genome‐wide methylation landscape during somatic embryogenesis in Medicago truncatula reveals correlation between Tnt1 retrotransposition and hyperactive methylation regions

Raja Sekhar Nandety, Sunhee Oh, Hee‐Kyung Lee, Nick Krom, more

The Plant Journal > 119 > 1 > 557 - 576

Medicago truncatula is a model legume for fundamental research on legume biology and symbiotic nitrogen fixation. Tnt1, a retrotransposon from tobacco, was used to generate insertion mutants in M. truncatula R108. Approximately 21 000 insertion lines have been generated and publicly available. Tnt1 retro‐transposition event occurs during somatic embryogenesis (SE), a pivotal process that triggers...

article

Hypomethylation‐associated LINC00987 downregulation induced lung adenocarcinoma progression by inhibiting the phosphorylation‐mediated degradation of SND1

Qi Lai, Yulin Wan, Yingqian Zhang, Yingzhao Huang, more

Molecular Carcinogenesis > 63 > 7 > 1260 - 1274

DNA methylation, an epigenetic regulatory mechanism dictating gene transcription, plays a critical role in the occurrence and development of cancer. However, the molecular underpinnings of LINC00987 methylation in the regulation of lung adenocarcinoma (LUAD) remain elusive. This study investigated LINC00987 expression in LUAD patients through analysis of The Cancer Genome Atlas data sets. Quantitative...

article

Cross‐selective Deoxygenative Coupling of Aliphatic Alcohols: Installation of Methyl Groups including Isotopic Labels by Nickel Catalysis

Patricia C. Lin, Chloe D. Wong, Elizabeth R. Jarvo

Angewandte Chemie International Edition > 63 > 24 > n/a - n/a

Nickel‐catalyzed cross‐electrophile coupling reactions of two aliphatic alcohol derivatives remain a challenge. Herein, we report a nickel‐catalyzed reductive methylation reaction of aliphatic mesylates with methyl tosylate. This reaction provides straightforward access to compounds bearing aliphatic methyl groups from alkyl alcohol derivatives. Isotopically labelled substrates and reagents can be...

article

Cross‐selective Deoxygenative Coupling of Aliphatic Alcohols: Installation of Methyl Groups including Isotopic Labels by Nickel Catalysis

Patricia C. Lin, Chloe D. Wong, Elizabeth R. Jarvo

Angewandte Chemie > 136 > 24 > n/a - n/a

Nickel‐catalyzed cross‐electrophile coupling reactions of two aliphatic alcohol derivatives remain a challenge. Herein, we report a nickel‐catalyzed reductive methylation reaction of aliphatic mesylates with methyl tosylate. This reaction provides straightforward access to compounds bearing aliphatic methyl groups from alkyl alcohol derivatives. Isotopically labelled substrates and reagents can be...

article

Adenosine kinase inhibits β‐cell proliferation by upregulating DNA methyltransferase 3A expression

Ting Chen, Jiayu Yu, Xin Guo, Siqi Wang, more

Diabetes, Obesity and Metabolism > 26 > 7 > 2956 - 2968

Aim To investigate the effects of adenosine kinase (ADK), a key enzyme in determining intracellular adenosine levels, on β cells, and their underlying mechanism. Methods Genetic animal models and transgenic immortalized cells were applied to study the effect of ADK on islet beta‐cell proliferation and function. The beta‐cell mass and response to glucose were measured in vivo using mice with beta‐cell‐specific...

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Search results

HPV DNA genotyping and methylation of gene p16INK4A in cervical LSIL

Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile

Amino Acids as biomarkers in the SOD1G93A mouse model of ALS

Heterogeneous catalysts based on B/P/O for the monoetherification of 1,2-dihydroxybenzene in the gas phase

Protein Modifications During Early Embryo Development

Fluorescence in situ hybridization‐negative intra‐articular myxoid liposarcoma with complex rearrangements involving EWSR1::DDIT3 detected using nanopore sequencing

Downregulation of C1R promotes hepatocellular carcinoma development by activating HIF‐1α‐regulated glycolysis

Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions

Deep learning can predict subgenome dominance in ancient but not in neo/synthetic polyploidized genomes

Diagnostic value for methylation in cervical cancer based on a small‐molecule fluorescent probe targeting DNMT1

A methylation‐related lncRNA‐based prediction model in lung adenocarcinomas

Betaine activates the Nrf2‐Keap1‐ARE pathway by increasing the methylation level of Keap1 DNA promoter

An RRM domain protein SOE suppresses transgene silencing in rice

Single generation epigenetic change in captivity and reinforcement in subsequent generations in a delta smelt (Hypomesus transpacificus) conservation hatchery

PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas

Genome‐wide methylation landscape during somatic embryogenesis in Medicago truncatula reveals correlation between Tnt1 retrotransposition and hyperactive methylation regions

Hypomethylation‐associated LINC00987 downregulation induced lung adenocarcinoma progression by inhibiting the phosphorylation‐mediated degradation of SND1

Cross‐selective Deoxygenative Coupling of Aliphatic Alcohols: Installation of Methyl Groups including Isotopic Labels by Nickel Catalysis

Cross‐selective Deoxygenative Coupling of Aliphatic Alcohols: Installation of Methyl Groups including Isotopic Labels by Nickel Catalysis

Adenosine kinase inhibits β‐cell proliferation by upregulating DNA methyltransferase 3A expression

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