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Plants from Suriname (South-America) and several Annona species, including A. muricata, A. ckerimolia, A. montana and A. glabra were screened for 5-HT 1A receptor binding activity by ligand-binding-studies (LBS). Crude extracts of all Annona species and from Hibiscus bifurcatus, Irlbarchia purpurascens and Scoparia dulcis showed high activity. The isoquinoline alkaloids asimilobine (1), nornuciferine...
Ligand-binding-studies on twelve different receptors were used for screening extracts from plants from Suriname (South-America). The results on 5-HT 1A , A 1 and NMDA receptors promote further investigation of Microtea debilis, Hibiscus bifurcatus, Irlbarchia purpurascens, Miconia ciliata and Mimosa myriadena.
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