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The formation of a glial scar after spinal cord injury (SCI) is one of the inhibitory factors for axonal regeneration. The cellular structure of a glial scar is mainly composed of reactive astrocytes that overexpress the intermediate filament (IF) proteins such as glial fibrillary acidic protein (GFAP) and vimentin. These proteins work as both physical and biochemical barriers for axonal growth in...
Small interfering RNA (siRNA) induced posttranscriptional gene silencing (PTGS) has been an efficient method for genetic and molecular analysis of certain developmental and physiological processes and represented a potential strategy for both controlling virus replication and developing therapeutic products. However, there are limitations for the methods currently used to deliver siRNA into cells...
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