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Items from 1 to 20 out of 916 results

article

Antenatal pyelonephritis hospitalisation trends, risk factors and associated adverse outcomes: A retrospective cohort study

Christy Gandhi, Timothy Wen, Lilly Y. Liu, Whitney A. Booker, more

BJOG: An International Journal of Obstetrics & Gynaecology > 131 > 12 > 1640 - 1649

Objective To analyse trends, risk factors and adverse outcomes associated with antenatal pyelonephritis hospitalisations. Design Retrospective cohort. Setting A national sample of US delivery hospitalisations with associated antenatal hospitalisations. Population US delivery hospitalisations in the Nationwide Readmissions Database from 2010 to 2020. Methods Antenatal hospitalisations with...

article

Intraoperative Mean Arterial Pressure and Postoperative Delayed Graft Function in Kidney Transplantation: Evaluating Three Commonly Used Thresholds

Chinnarat Pongpruksa, Nutchanok Khampitak, Drew Chang, Suphamai Bunnapradist, more

Clinical Transplantation > 38 > 9 > n/a - n/a

Background Delayed graft function (DGF) is a common early complication after kidney transplantation (KT) and is associated with various long‐term adverse outcomes. Despite numerous studies on hemodynamic management, the optimal hemodynamic goals during KT remain unclear. In this retrospective study, we aimed to investigate if three mean artery pressure (MAP) thresholds (≤75, 80, and 85 mmHg) that...

article

Trends in hospitalization for cardio‐renal disease and mortality in people with type 1 diabetes in England, 2009–2019

Naomi Holman, Bob Young, Edward W. Gregg, Nick Wareham, more

Diabetes, Obesity and Metabolism > 26 > 10 > 4357 - 4365

Aim To assess mortality and complication trends in people with type 1 diabetes during the 11 years before the SARS‐CoV2 pandemic (2009–2019). Materials and Methods Sequential cohorts of people in England with type 1 diabetes aged ≥20 years from the National Diabetes Audit (2006/2007 to 2016/2017) were analysed. Discretized Poisson regression models, adjusted for age, sex, ethnicity, socioeconomic...

article

Gold Nanoparticle Transport in the Injured Kidneys with Elevated Renal Function Biomarkers

Xuhui Ning, Yuncheng Zhong, Qi Cai, Yaohong Wang, more

Advanced Materials > 36 > 36 > n/a - n/a

Renal function biomarkers such as serum blood urea nitrogen (BUN) and creatinine (Cr) serve as key indicators for guiding clinical decisions before administering kidney‐excreted small‐molecule agents. With engineered nanoparticles increasingly designed to be renally clearable to expedite their clinical translation, understanding the relationship between renal function biomarkers and nanoparticle transport...

article

Regional socioeconomic deprivation associated with the use of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists in adults with type 2 diabetes in Germany

Marie Auzanneau, Jochen Seufert, Stefan Zimny, Thomas Haak, more

Diabetes, Obesity and Metabolism > 26 > 9 > 4116 - 4120

article

Targeting polo‐like kinase 1 to treat kidney diseases

Hrushikesh Kulkarni, Neha Dagar, Anil Bhanudas Gaikwad

Cell Biochemistry and Function > 42 > 5 > n/a - n/a

Globally, ∼850 million individuals suffer from some form of kidney disease. This staggering figure underscores the importance of continued research and innovation in the field of nephrology to develop effective treatments and improve overall global kidney health. In current research, the polo‐like kinase (Plk) family has emerged as a group of highly conserved enzyme kinases vital for proper cell cycle...

article

Decisional needs in people with kidney failure, their relatives and health professionals about end‐of‐life care options: A qualitative interview study

Louise Engelbrecht Buur, Hilary Louise Bekker, Lotte Ørneborg Rodkjær, Anne Kvist, more

Journal of Advanced Nursing > 80 > 8 > 3345 - 3358

Aim To investigate the decisional needs in Denmark of people with kidney failure, relatives, and health professionals when planning end‐of‐life care. Design A qualitative interview study. Methods Individual semi‐structured interviews were carried out with people with kidney failure, relatives and health professionals from November 2021 to June 2022. Malterud's systematic text condensation was...

article

Prevalence of kidney health genetic variants in adults with sickle cell nephropathy

Maria Armila Ruiz, Xu Zhang, M. Adela Mansilla, Rima S. Zahr, more

British Journal of Haematology > 205 > 1 > 316 - 319

The pathophysiology and genetic risk for sickle cell disease (SCD)‐related chronic kidney disease (CKD) are not well understood. In 70 adults with SCD‐related CKD and without APOL1 inherited in a high‐risk pattern, 24 (34%) had pathogenic variants in candidate genes using KidneySeq™. A moderate impact INF2 variant was observed in 20 (29%) patients and those with 3 versus 0–2 pathogenic or moderate...

article

Determinants of serious health outcome‐free status in middle‐aged and older people with dysglycaemia: Exploratory analysis of the ORIGIN trial

Kamel Mohammedi, Sibylle Hess, Matthew McQueen, Marie Pigeyre, more

Diabetes, Obesity and Metabolism > 26 > 8 > 3272 - 3280

Aim To assess clinical and biochemical measurements that can identify people with dysglycaemia (i.e. diabetes or pre‐diabetes) who remain free of serious outcomes during follow‐up. Materials and Methods We conducted exploratory analyses using data from the Outcomes Reduction with an Initial Glargine Intervention (ORIGIN) study to identify independent determinants of outcome‐free status in 12 537...

article

Using ChatGPT for Kidney Transplantation: Perceived Information Quality by Race and Education Levels

Jihye Lee, Jeeyun Park, Hwarang Stephen Han

Clinical Transplantation > 38 > 7 > n/a - n/a

Background Kidney transplantation is a complex process requiring extensive preparation and ongoing monitoring. Artificial intelligence (AI)‐powered chatbots hold potential for providing accessible health information, but our understanding of their role in offering health advice for kidney transplantation and how individuals assess such advice remains limited. This study investigates how individuals...

article

“It was classed as a nonemergency”: Women's experiences of kidney disease and preconception decision‐making, family planning, and parenting in the United Kingdom during COVID‐19

Leah Mc Laughlin, Jane Noyes, Barbara Neukirchinger, Denitza Williams, more

Perspectives on Sexual and Reproductive Health > 56 > 2 > 147 - 157

Objectives To investigate the experiences of women with kidney disease, residing in the United Kingdom (UK), living through the first 18 months of the COVID‐19 pandemic with specific focus on preconception decision‐making, family planning, and parenting. Methods We conducted a mixed‐methods study, comprising an online survey and follow‐up interviews, with UK‐resident women aged 18–50. Results...

article

Proteomics of urinary small extracellular vesicles in early diagnosis of kidney diseases in children‐expectations and limitations

Klaudia Korecka, Marta Gawin, Agnieszka Pastuszka, Mirosław Partyka, more

PROTEOMICS > 24 > 11 > n/a - n/a

The primary function of the kidneys is to maintain systemic homeostasis (disruption of renal structure and function results in multilevel impairment of body function). Kidney diseases are characterized by a chronic, progressive course and may result in the development of chronic kidney disease (CKD). Evaluation of the composition of the proteome of urinary small extracellular vesicles (sEVs) as a...

article

Body mass index and cardiorenal outcomes in the EMPEROR‐Preserved trial: Principal findings and meta‐analysis with the DELIVER trial

Naveed Sattar, Javed Butler, Matthew M.Y. Lee, Josephine Harrington, more

European Journal of Heart Failure > 26 > 4 > 900 - 909

Aims Both low and high body mass index (BMI) are associated with poor heart failure outcomes. Whether BMI modifies benefits of sodium–glucose cotransporter 2 inhibitors (SGLT2i) in heart failure with preserved ejection fraction (HFpEF) requires further investigation. Methods and results Using EMPEROR‐Preserved data, the effects of empagliflozin versus placebo on the risks for the primary outcome...

article

Longitudinal changes in diffusion tensor imaging in hemodialysis patients

Wesley T. Richerson, Brian D. Schmit, Dawn F. Wolfgram

Hemodialysis International > 28 > 2 > 178 - 187

Introduction Hemodialysis patients have increased white matter and gray matter pathology in the brain relative to controls based on MRI. Diffusion tensor imaging is useful in detecting differences between hemodialysis and controls but has not identified the expected longitudinal decline in hemodialysis patients. In this study we implemented specialized post‐processing techniques to reduce noise to...

article

Effectiveness of mindfulness‐based interventions delivered via technology versus therapist among patients on peritoneal dialysis at an outpatient clinic in Singapore

Mei Yi Aw, Stacey Henderson, Yiong Huak Chan, Kinjal Doshi, more

International Journal of Nursing Practice > 30 > 2 > n/a - n/a

Aims This study aimed to (i) evaluate the effectiveness of mindfulness‐based interventions in improving self‐efficacy, reducing stress and anxiety among peritoneal dialysis patients, and (ii) compare the most effective method of mindfulness based interventions. Methods This randomized three‐arm controlled trial recruited first‐time peritoneal dialysis patients from the peritoneal dialysis outpatient...

article

Alterations in oxidative stress biomarkers and helper T‐cell subgroups in patients with periodontitis and IgA nephropathy

Jinfeng Li, Yanjun Zhang, Hao Lu, Zhiwei Li, more

Journal of Periodontal Research > 59 > 2 > 325 - 335

Objective Investigating the changes in the oxidative stress levels and helper T lymphocyte (Th) subsets in patients with periodontitis and IgA nephropathy (IgAN) to determine their relationship. Background IgAN has a high prevalence, poor prognosis, and no effective cure. Accumulating evidence has implicated a close relationship between periodontitis and chronic kidney diseases, in which both IgAN...

article

Cardiovascular and renal outcomes with varying degrees of kidney disease in high‐risk people with type 2 diabetes: An epidemiological analysis of data from the AMPLITUDE‐O trial

Hertzel C. Gerstein, Rajibul Mian, Chinthanie Ramasundarahettige, Kelley R. H. Branch, more

Diabetes, Obesity and Metabolism > 26 > 4 > 1216 - 1223

Aims To estimate the incidence of a major adverse cardiovascular event (MACE) and a composite kidney outcome across estimated glomerular filtration rate (eGFR) and urine albumin‐to‐creatinine ratio (UACR) levels, and to determine whether efpeglenatide's effect varies with these indices. Materials and Methods AMPLITUDE‐O trial data were used to estimate the relationship of eGFR, UACR, and Kidney...

article

A quantitative assessment of renal function utilizing albuminuria in pediatric heart transplant recipients

Erik L. Frandsen, Richard A. Kronmal, Erin A. Albers, Joshua M. Friedland‐Little, more

Clinical Transplantation > 38 > 2 > n/a - n/a

Introduction Kidney disease is common after pediatric heart transplantation. Serum creatinine‐based glomerular filtration rate is the most frequently reported measure of kidney function. Albuminuria is an additional marker of kidney dysfunction and is not well described in this population. In this study, we evaluate the prevalence and degree of albuminuria and describe clinical factors associated...

article

The effect of teach‐back versus pictorial image educational methods on knowledge of renal dietary restrictions in elderly hemodialysis patients with low baseline health literacy

Mohammad Sadegh Mozafari, Fereshteh Besharati, Parand Pourghane, Bahareh Gholami‐Chaboki

Hemodialysis International > 28 > 1 > 92 - 97

Introduction Adherence to renal dietary restrictions is an important method for minimizing complications in dialysis patients. This study aimed to investigate the effect of teach‐back versus pictorial image educational methods on knowledge of renal dietary restrictions among elderly hemodialysis patients in Iran. Selected markers of diet and kidney function were also measured. Methods Sixty‐nine...

article

Long noncoding RNA: An emerging diagnostic and therapeutic target in kidney diseases

Kumaresan Ramanathan, Minale Fekadie, Giri Padmanabhan, Henok Gulilat

Cell Biochemistry and Function > 42 > 1 > n/a - n/a

Long noncoding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury, chronic kidney disease, and renal cell carcinoma. Understanding the roles of lncRNAs in kidney...

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Search results

Antenatal pyelonephritis hospitalisation trends, risk factors and associated adverse outcomes: A retrospective cohort study

Intraoperative Mean Arterial Pressure and Postoperative Delayed Graft Function in Kidney Transplantation: Evaluating Three Commonly Used Thresholds

Trends in hospitalization for cardio‐renal disease and mortality in people with type 1 diabetes in England, 2009–2019

Gold Nanoparticle Transport in the Injured Kidneys with Elevated Renal Function Biomarkers

Regional socioeconomic deprivation associated with the use of sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists in adults with type 2 diabetes in Germany

Targeting polo‐like kinase 1 to treat kidney diseases

Decisional needs in people with kidney failure, their relatives and health professionals about end‐of‐life care options: A qualitative interview study

Prevalence of kidney health genetic variants in adults with sickle cell nephropathy

Determinants of serious health outcome‐free status in middle‐aged and older people with dysglycaemia: Exploratory analysis of the ORIGIN trial

Using ChatGPT for Kidney Transplantation: Perceived Information Quality by Race and Education Levels

“It was classed as a nonemergency”: Women's experiences of kidney disease and preconception decision‐making, family planning, and parenting in the United Kingdom during COVID‐19

Proteomics of urinary small extracellular vesicles in early diagnosis of kidney diseases in children‐expectations and limitations

Body mass index and cardiorenal outcomes in the EMPEROR‐Preserved trial: Principal findings and meta‐analysis with the DELIVER trial

Longitudinal changes in diffusion tensor imaging in hemodialysis patients

Effectiveness of mindfulness‐based interventions delivered via technology versus therapist among patients on peritoneal dialysis at an outpatient clinic in Singapore

Alterations in oxidative stress biomarkers and helper T‐cell subgroups in patients with periodontitis and IgA nephropathy

Cardiovascular and renal outcomes with varying degrees of kidney disease in high‐risk people with type 2 diabetes: An epidemiological analysis of data from the AMPLITUDE‐O trial

A quantitative assessment of renal function utilizing albuminuria in pediatric heart transplant recipients

The effect of teach‐back versus pictorial image educational methods on knowledge of renal dietary restrictions in elderly hemodialysis patients with low baseline health literacy

Long noncoding RNA: An emerging diagnostic and therapeutic target in kidney diseases

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