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Objective
To confirm and investigate why pathological high‐frequency oscillations (pHFOs), including ripples (80–200 Hz) and fast ripples (200–600 Hz), are generated during the UP‐DOWN transition of the slow wave and if information transmission mediated by ripple temporal coupling is disrupted in the seizure‐onset zone (SOZ).
Methods
We isolated 217 total units from 175.95 intracranial electroencephalography...
How responsive neurostimulation (RNS) decreases seizure frequency is unclear. Stimulation may alter epileptic networks during inter‐ictal epochs. Definitions of the epileptic network vary but fast ripples (FRs) may be an important substrate. We, therefore, examined whether stimulation of FR‐generating networks differed in RNS super responders and intermediate responders. In 10 patients, with subsequent...
Objective
High‐frequency oscillations (HFOs) have shown promising utility in the spatial localization of the seizure onset zone for patients with focal refractory epilepsy. Comparatively few studies have addressed potential temporal variations in HFOs, or their role in the preictal period. Here, we introduce a novel evaluation of the instantaneous HFO rate through interictal and peri‐ictal epochs...
The current study aimed to investigate the spatial and temporal patterns of high‐frequency oscillations (HFOs) in the intra‐/extrahippocampal areas during epileptogenesis. Local field potentials were bilaterally recorded from hippocampus (CA1), thalamus, motor cortex, and prefrontal cortex in 13 rats before and after intrahippocampal kainic acid (KA) lesions. HFOs in the ripple (100‐200 Hz) and fast...
Objective
Ripples (80–150 Hz) recorded from clinical macroelectrodes have been shown to be an accurate biomarker of epileptogenic brain tissue. We investigated coupling between epileptiform spike phase and ripple amplitude to better understand the mechanisms that generate this type of pathologic ripple (pRipple) event.
Methods
We quantified phase amplitude coupling (PAC) between epileptiform electroencephalography...
The pathophysiology of Parkinson's disease (PD) has been related to excessive beta band oscillations in the basal ganglia. Recent recordings from the subthalamic nucleus of PD patients showed that beta oscillations show strong cross‐frequency coupling with high‐frequency oscillations (>200 Hz). However, little is known about the characteristics and functional properties of these oscillations. We...
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