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article

Adult xanthogranuloma in oral cavity and ultrasound‐guided resection surgery: A case report

Rafael Aguiar Sousa, Pedro Henrique Almeida Figueiredo, Rejane Christina Lopes Paiva, Marcelo Drummond Naves, more

Aim To present a rare case of xanthogranuloma affecting the oral cavity of an adult man and to highlight the utility of ultrasound in demonstrating its sonographic features and guiding the surgical procedure. Materials and Methods Description of a rare case of oral xanthogranuloma in an adult patient, with treatment performed using ultrasound. This tool provides safety as it functions as a real‐time...

article

A retrospective analysis of molecular testing in cytologically indeterminate thyroid nodules with histologic correlation: Experience at a heterogenous multihospital system

Gloria H. Sura, Michael J. Thrall, John Rogers, Parsa Hodjat, more

Diagnostic Cytopathology > 52 > 2 > 82 - 92

Introduction Thyroid malignancy is one of the most common types of cancer in developed nations. Currently, fine‐needle aspiration cytology (FNAC) is the most practical screening test for thyroid nodules. However, cytologically indeterminate samples comprise approximately 15%–30% of cases. These include cases classified as atypia of undetermined significance (AUS), follicular neoplasm (FN), and suspicious...

article

Application of the Milan System for Reporting Salivary Gland Cytopathology to cystic salivary gland lesions

Zahra Maleki, Derek B. Allison, Monica Butcher, Satomi Kawamoto, more

Cancer Cytopathology > 129 > 3 > 214 - 225

Background Cystic salivary gland lesions present diagnostic challenges on fine‐needle aspiration (FNA) specimens that are related to sampling limitations and a broad differential diagnosis. This study evaluated the benefit of applying the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) to a series of cystic salivary gland lesions. Methods The pathology archives at the Johns Hopkins...

article

Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi‐institutional study

Derek B. Allison, Alexander P. Smith, Daniel An, James Adam Miller, more

Cancer Cytopathology > 129 > 1 > 43 - 52

Background The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has established distinct diagnostic categories for reporting cytopathological findings, and each is associated with a defined risk of malignancy (ROM). However, the ROM is applied at the overall category level and is not specific for particular morphological entities within a category. Here, the diagnostic performance...

article

Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma

Andrew R. Larson, Jacquelyn Kemmer, Eric Formeister, Ivan El‐Sayed, more

The Laryngoscope > 130 > 7 > 1715 - 1720

Objective In small (≤2 cm) oral tongue squamous cell carcinoma (OTSCC), we sought to clarify the contribution of pathologic features including perineural invasion (PNI), lymphovascular invasion (LVI), and worst pattern of invasion‐5 (WPOI‐5) to clinical outcomes relative to tumor depth of invasion (DOI) of > or ≤ 4 mm. Methods Cases of ≤2 cm OTSCC treated surgically between 2000 and 2017 at...

article

Cystic major salivary gland lesions: Utilizing fine needle aspiration to optimize the clinical management of a broad and diverse differential diagnosis

Derek B. Allison, Austin M. McCuiston, Satomi Kawamoto, David W. Eisele, more

Diagnostic Cytopathology > 45 > 9 > 800 - 807

Introduction The use of fine‐needle aspiration (FNA) cytology for the preoperative evaluation of salivary gland lesions is an accepted but, currently, nonstandardized practice. More specifically, cystic major salivary gland lesions are relatively rare and can be very challenging to diagnose on FNA due to low cellularity and an incredibly broad differential diagnosis. The purpose of this study was...

article

Laryngocele: A Rare Case Report and Review of Literature

Ruchika Juneja, Nikhil Arora, Ravi Meher, Pankhuri Mittal, more

Indian Journal of Otolaryngology and Head & Neck Surgery > 2019 > 71 > 1 > 147-151

Laryngocele is an abnormal cystic dilatation of the saccule of the larynx. It communicates with the laryngeal lumen and contains air. Laryngocele can be classified as internal (within the larynx), external (outside the larynx) and mixed (both). It is a rare entity. Hereby, we are reporting a case of laryngocele, which presented to us with a diagnostic quandary. After confirming the diagnosis by radiology,...

article

Transoral robotic surgery for management of cervical unknown primary squamous cell carcinoma: Updates on efficacy, surgical technique and margin status

Mathew Geltzeiler, Sean Doerfler, Meghan Turner, William Greer Albergotti, more

Oral Oncology > 2017 > 66 > C > 9-13

Management of cervical unknown primary squamous cell carcinoma (CUP) has evolved with the introduction of transoral robotic surgery (TORS).1. To describe the efficacy of TORS lingual and palatine tonsillectomy in identifying the primary site of malignancy. 2. To explore how the extent of surgery affects diagnostic yield. 3. To report margin status of TORS resections.A retrospective, single-center...

article

Predictors of extracapsular extension in HPV-associated oropharyngeal cancer treated surgically

Mathew Geltzeiler, Daniel Clayburgh, John Gleysteen, Neil D. Gross, more

Oral Oncology > 2017 > 65 > C > 89-93

Extracapsular extension (ECE) in cervical metastatic lymph nodes remains an indication for adding chemotherapy for patients with oropharyngeal squamous cell carcinoma (OPSCC). The aim of this study is to identify specific imaging characteristics on computed tomography (CT) scan that are predictive of ECE in order to better risk stratify patients preoperatively.A single cohort study was performed using...

chapter

Salivary Gland and Other Head and Neck Structures

Conrad Schuerch

Handbook of Practical Immunohistochemistry > 173-196

This chapter is designed as an easy reference for the practicing pathologist aiming to solve diagnostic problems in head and neck pathology by immunohistochemistry (IHC). It is a collection of 38 practical tables including tables for commonly used antibodies, IHC reactions in normal salivary gland, IHC reactions in common salivary gland and head and neck tumors, and IHC reactions to resolve differential...

article

Synchronous Ipsilateral Parotid Tumors with Cytologic–Histologic Correlation

Kristina Gvozdjan, John V. Groth, Tushar N. Patel, Grace Guzman, more

Head and Neck Pathology > 2016 > 10 > 2 > 265-268

Synchronous ipsilateral tumor formation within a major salivary gland is a very rare event. In this case, a 54-year-old female tobacco smoker presented with a slowly enlarging left parotid gland. Computed tomography of the neck demonstrated a solid mass superficial to a cystic mass in the deep lobe of the gland. Ultrasound-guided fine needle aspiration yielded oncocytic cells, lymphoid cells, and...

article

Dr. Andrew Huvos (1934–2006) Retrospective: A Tribute to the Pathologist and the Man

Diane L. Carlson

Head and Neck Pathology > 2013 > 7 > 1 > 1-4

Andrew G. Huvos was born in communist Budapest, Hungary, in March of 1934. At twenty-four he immigrated to New York City, working as a cytotechnologist at Delafield Hospital. Dr. Huvos attended the University of Gottingen Medical School in Germany, where he was awarded his MD degree. He completed a 1-year internship at New York Hospital, going on to Residency at Delafield Hospital and Fellowship at...

article

Lateral dermoid cyst of the floor of mouth: Unusual radiologic and pathologic findings

Harrison W. Lin, Amanda L. Silver, Mary E. Cunnane, Peter M. Sadow, more

Auris Nasus Larynx > 2011 > 38 > 5 > 650-653

A lateral dermoid cyst is a rare lesion of the floor of mouth, with only 12 cases reported in the literature. We describe the case of a 60-year-old man with a slowly enlarging mass in the submandibular region. Magnetic resonance imaging demonstrated a lesion containing multiple uniformly rounded foci, creating a “sack-of-marbles” appearance. Needle aspirations showed atypical findings, and the mass...

article

The Spectrum of Gnathic Osteosarcoma: Caveats for the Clinician and the Pathologist

Ricardo J. Padilla, Valerie A. Murrah

Head and Neck Pathology > 2011 > 5 > 1 > 92-99

Seven expansile jaw lesions in patients ranging from 7 to 63 years are presented to illustrate diagnostic and management issues pertaining to cases ultimately proven to be gnathic osteosarcoma (GO). Six of the cases in our series were low-grade osteoblastic and one high-grade chondroblastic. None of our cases exhibited the characteristic “sunburst” radiopaque appearance described for GO. All of our...

article

Spontaneous infarction of pleomorphic adenoma: Report of a case simulating malignancy on fine‐needle cytology sample

Franco Fulciniti, Nunzia Simona Losito, Gerardo Botti, Marco Manola, more

Diagnostic Cytopathology > 38 > 6 > 430 - 434

Ischemic or hemorrhagic infarction has been described as an uncommon but possible complication of fine‐needle cytology sampling in numerous organs, more frequently the thyroid, the salivary glands, the breast, the lymph node, and the kidney. In these situations, infarction appears to be directly related to the vascular disturbances caused by needle sampling, though fine this latter might be. One case...

article

Sclerosing polycystic adenosis of the parotid gland: Report of one case diagnosed by fine‐needle cytology with in situ malignant transformation

Franco Fulciniti, Nunzia Simona Losito, Franco Ionna, Francesco Longo, more

Diagnostic Cytopathology > 38 > 5 > 368 - 373

Sclerosing polycystic adenosis (SPA) is a rare pathological condition affecting the salivary glands, first described by Smith etal. in 1996. Even though this lesion is being increasingly diagnosed, less than 50 cases have been published in the world literature to date. In line with numerous other pathological analogies between breast and salivary gland lesions, SPA shares with fibrocystic disease...

article

Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome

Shi Wei, William Carroll, Audrey Lazenby, Walter Bell, more

Annals of Diagnostic Pathology > 2008 > 12 > 6 > 415-425

Sinonasal teratocarcinosarcoma is a highly malignant, polymorphous neoplasm that combines features of carcinosarcoma and teratoma. We describe the clinicopathologic features and management of a well-documented example of this unique entity that involved a 41-year-old Hispanic man. The patient presented with a history of multiple episodes of epistaxis, nasal obstruction and frontal headaches. Computerized...

article

Hereditary Paraganglioma of the Nasopharynx

Nasser Said-Al-Naief, Junu Ojha

Head and Neck Pathology > 2008 > 2 > 4 > 272-278

Head and neck paragangliomas are rare neuroendocrine tumors derived from neural crest cells of parasympathetic ganglia or the widely dispersed neuroendocrine cells of the head and neck region. Paragangliomas of the sinonasal tract and nasopharynx are rare. The clinicopathologic features of this unique example of a hereditary, nasopharyngeal paraganglioma, and selective entities that are included in...

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