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Recently, epidemiologists tend to focus on the association of health outcomes with combinations of exposures (composites), defined a-priori or a-posteriori. Such composites appear often in nutritional (dietary patterns) and genetic (genetic scores) epidemiology. The estimated associations, however, have not been linked to those of the components of the composite, at least in a systematic way. We considered...
We present the most comprehensive comparison to date of the predictive benefit of genetics in addition to currently used clinical variables, using genotype data for 33 single‐nucleotide polymorphisms (SNPs) in 1,547 Caucasian men from the placebo arm of the REduction by DUtasteride of prostate Cancer Events (REDUCE®) trial. Moreover, we conducted a detailed comparison of three techniques for incorporating...
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