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Krebs ist eine der Haupttodesursachen weltweit. Die funktionelle Inaktivierung von Tumorsuppressoren, hauptsächlich durch Mutationen in den entsprechenden Genen, ist ein Schlüsselereignis in der Krebsentstehung. Das “fragile histidine triade protein” (Fhit) ist ein Tumorsuppressor, der in verschiedenen Krebsarten verändert ist. Fhit hat Diadenosintriphosphat‐Hydrolase‐Aktivität, aber obwohl die Reduktion...
Cancer is a leading cause of death worldwide. Functional inactivation of tumor suppressor proteins, mainly by mutations in the corresponding genes, is a key event in cancer development. The fragile histidine triade protein (Fhit) is a tumor suppressor that is frequently affected in different cancer types. Fhit possesses diadenosine triphosphate hydrolase activity, but although reduction of its enzymatic...
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