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ObjectivesThis study aimed to design a fixed‐dose combination dosage form which provides a sustained release profile for both the freely water‐soluble metformin HCl and the poorly soluble gliclazide, two antidiabetic compounds used to treat diabetes mellitus.
MethodsHot‐melt co‐extrusion was used as an innovative manufacturing technique for a pharmaceutical fixed‐dose combination product. In this...