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Background Mild cognitive impairment (MCI) is an intermediate phase between normal aging and dementia. Since a majority of amnestic MCI (aMCI) cases progress to Alzheimer’s disease (AD), it is considered the prodromal stage of AD and, therefore, a treatment target for the prevention of further cognitive decline. However, there is no approved treatment for MCI at present. Kami Guibi-tang (KGT) is a...
Diuron and its biodegradation metabolites were recently reported to cause alterations in plasma steroid hormone concentrations with subsequent impacts on reproductive development in fish. Since steroid hormone biosynthesis is regulated through neurotransmission of the central nervous system (CNS), studies were conducted to determine whether neurotransmitters that control hormone biosynthesis could...
A major challenge in the elucidation of brain neurotransmitter events in vivo in the laboratory and in the operating room has been the development of methods to record neurotransmitters in the CNS on a second-by-second time scale. Microdialysis methods have been widely employed but are limited due to their inherent slow sampling rates (1-20 min) and poor exchange (~10-20%) of neurotransmitters. We...
Although brain neurotransmitter (BN) won Nobel Prize in 2000, their non-invasive measurement had been a challenge for internal secretion maladjustment of human brain. Our objective is to study indirect and non-invasive BN measurement validity through novel combination methods of auricular point's infrared image and wavelet analysis. For 10-subjective with half of male graduate students we made three...
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