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Items from 1 to 20 out of 95 results

article

Safety and effectiveness of SARS‐CoV‐2 vaccines for patients with intractable hepatobiliary diseases: A multicenter, questionnaire‐based, cross‐sectional study

Ayaka Tanifuji, Satoko Ohfuji, Kosuke Matsumoto, Masanori Abe, more

Hepatology Research > 54 > 7 > 706 - 715

Aim There are few data regarding the safety and effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines in patients with intractable hepatobiliary diseases. We conducted a multicenter, questionnaire‐based, cross‐sectional study to determine the safety and effectiveness of the SARS‐CoV‐2 vaccines in Japanese patients with intractable hepatobiliary disease. Methods...

article

Correlation between hepatic venous pressure gradient and portal pressure gradient in patients with autoimmune cirrhotic portal hypertension and collateral branches of the hepatic vein

Bowen Liu, Dan Zhang, Chengbin Dong, Zhendong Yue, more

Hepatology Research > 53 > 11 > 1084 - 1095

Aim To assess the correlation and agreement between hepatic venous pressure gradient (HVPG) and portal pressure gradient (PPG) in patients with autoimmune liver diseases (ALD) and portal hypertension, and to investigate the extent to which hepatic vein collateralization affects the accuracy of this assessment. Methods Ninety‐eight patients with ALD between 2017 and 2021 who underwent transjugular...

article

Liver abnormalities in celiac disease and response to gluten free diet: A systematic review and meta‐analysis

Anuraag Jena, Praveen Kumar‐M, Antriksh Kumar, Chhagan Lal Birda, more

Journal of Gastroenterology and Hepatology > 38 > 1 > 11 - 22

Background and Aim Liver involvement in celiac disease (CeD) is known but its various etiologies and the effect of gluten free diet (GFD) on it is understudied. Methods We searched PubMed, Medline and Embase databases from date of inception to March 7, 2022, to look for studies reporting on CeD and liver abnormalities. Pooled proportion of CeD patients with deranged transaminases, etiologies of...

article

Metabolomics‐based researches in autoimmune liver disease: A mini‐review

Nurmeen Adil, Amna Jabbar Siddiqui, Syed Ghulam Musharraf

Scandinavian Journal of Immunology > 96 > 4 > n/a - n/a

Metabolomics offers a promising approach to studying metabolites in the biological system. It offers new opportunities to assess the disease progression and biomarker selection and also provides a pathophysiological understanding of the disease. Autoimmune liver disease is a major public health concern worldwide. Three main categories of this disease include autoimmune hepatitis (AIH), primary biliary...

article

Next‐generation sequencing in the evaluation of biliary strictures in patients with primary sclerosing cholangitis

Johannes F. Scheid, Matthew W. Rosenbaum, Eric M. Przybyszewski, Kumar Krishnan, more

Cancer Cytopathology > 130 > 3 > 215 - 230

Background Primary sclerosing cholangitis (PSC) is a well‐described risk factor for the development of cholangiocarcinoma (CCA). Early detection of CCA in these patients is of great importance because it expands options for therapeutic interventions, including liver transplantation. Current diagnostic tests for the evaluation of biliary strictures are limited to biliary brushing (BB) cytology and...

article

Machine learning in primary biliary cholangitis: A novel approach for risk stratification

Alessio Gerussi, Damiano Verda, Davide Paolo Bernasconi, Marco Carbone, more

Liver International > 42 > 3 > 615 - 627

Background & Aims Machine learning (ML) provides new approaches for prognostication through the identification of novel subgroups of patients. We explored whether ML could support disease sub‐phenotyping and risk stratification in primary biliary cholangitis (PBC). Methods ML was applied to an international dataset of PBC patients. The dataset was split into a derivation cohort (training set)...

article

Psychiatric comorbidity in childhood onset immune‐mediated diseases—A systematic review and meta‐analysis

Sabine Jansson, Mikkel Malham, Vibeke Wewer, Charlotte Ulrikka Rask

Acta Paediatrica > 111 > 3 > 490 - 499

Aim To estimate psychiatric comorbidity in childhood onset immune‐mediated inflammatory diseases (IMID). Methods The PRISMA guidelines were followed, and the protocol was registered at Prospero (ID: CRD42021233890). Literature was searched in PubMed, PsycINFO and Embase. Original papers on prevalence rates of diagnosed psychiatric disorders and/or suicide in paediatric onset inflammatory bowel...

article

Sarcopenia is highly prevalent in children with autoimmune liver diseases and is linked to visceral fat and parent‐perceived general health

Antoinette A. Amevor, Toshifumi Yodoshi, Andrew T. Trout, Jonathan R. Dillman, more

Liver International > 42 > 2 > 394 - 401

Background Patients with autoimmune hepatitis (AIH) and primary or autoimmune sclerosing cholangitis are at nutritional risk; their body composition and has not been extensively studied. We aimed to describe their body composition and identify clinical links. Methods Using magnetic resonance imaging (MRI), two reviewers segmented total psoas muscle area (tPMSA), visceral fat area (VFA) and subcutaneous...

article

Rates of decompensation, hepatocellular carcinoma and mortality in AMA‐negative primary biliary cholangitis cirrhosis

Binu V. John, Bassam Dahman, Yangyang Deng, Nidah S. Khakoo, more

Liver International > 42 > 2 > 384 - 393

Background The natural history of patients with anti‐mitochondrial antibody (AMA)‐negative Primary Biliary Cholangitis (PBC) cirrhosis has not been well defined, with prior studies showing discordant results. Furthermore, most studies of AMA‐negative PBC have limited numbers of patients with cirrhosis and liver‐related outcomes. Methods We investigated the association of AMA‐negative PBC and the...

article

Epstein–Barr virus status and immunosuppression use in paediatric autoimmune liver disease

Jeremy S. Nayagam, Michael A. Heneghan, Marianne Samyn, Deepak Joshi

Alimentary Pharmacology & Therapeutics > 55 > 4 > 455 - 463

Background Since azathioprine is associated with lymphoproliferative disorders in Epstein–Barr virus (EBV)‐naïve patients with inflammatory bowel disease, guidelines advise avoidance. No recommendations exist for autoimmune liver disease (AILD). Aims To evaluate EBV status and EBV‐related complications in paediatric AILD. Methods Single‐centre, retrospective, observational study of paediatric...

article

Bone microarchitecture in patients with autoimmune hepatitis

Constantin Schmidt, Julian Stürznickel, André Strahl, Ralf Oheim, more

Journal of Bone and Mineral Research > 36 > 7 > 1316 - 1325

In patients with autoimmune hepatitis (AIH), osteoporosis represents a common extrahepatic complication, which we recently showed by an assessment of areal bone mineral density (aBMD) via dual‐energy x‐ray absorptiometry (DXA). However, it is well established that bone quality and fracture risk does not solely depend on aBMD, but also on bone microarchitecture. It is currently not known whether AIH...

article

A nomogram based on pretreatment clinical parameters for the prediction of inadequate biochemical response in primary biliary cholangitis

Siyuan Tian, Yansheng Liu, Keshuai Sun, Xia Zhou, more

Journal of Clinical Laboratory Analysis > 34 > 11 > n/a - n/a

Background Ursodeoxycholic acid (UDCA) has been widely recommended as the first‐line drug for primary biliary cholangitis (PBC) in the current guidelines. However, its therapeutic effects are poor in nearly one‐third of patients. The early identification and intervention of these patients is crucial for delaying disease progression. Therefore, we explored risk factors for inadequate biochemical response...

article

Gut dysbiosis associated with clinical prognosis of patients with primary biliary cholangitis

Masanori Furukawa, Kei Moriya, Jiro Nakayama, Takako Inoue, more

Hepatology Research > 50 > 7 > 840 - 852

Aim Although some relationships between gut microbiota and liver diseases have been reported, it remains uncertain whether changes in gut microbiota owing to differences in race, food and living environment have similar effects. Response to ursodeoxycholic acid (UDCA) may predict the long‐term prognosis of patients with primary biliary cholangitis (PBC); however, little is known about the significance...

article

Increasing prevalence of primary biliary cholangitis in Victoria, Australia

Janine French, Ingrid Mei, Steve Simpson, Justin Ng, more

Journal of Gastroenterology and Hepatology > 35 > 4 > 673 - 679

Background and Aim The prevalence of primary biliary cholangitis (PBC) reported in different countries varies significantly and in some parts of the world appears to be increasing. The aim of this study was to determine the 2013 prevalence of PBC in Victoria, Australia, and to determine the time trend by comparing it with previous studies undertaken in 1991 and 2002. Methods Four case‐finding methods...

article

TIM‐3: An emerging target in the liver diseases

Lizhen Zhao, Guoyi Yu, Qi Han, Congxian Cui, more

Scandinavian Journal of Immunology > 91 > 4 > n/a - n/a

T cell immunoglobulin domain and mucin domain‐containing molecule 3 (TIM‐3) is found expression in the surface of terminally differentiated T cells and belongs to the TIM family of type Ⅰ transmembrane proteins. It binds to the ligand Galectin‐9 and mediates T cell apoptosis. As the research progresses, TIM‐3 is also expressed in Th17, NK, monocyte, which binds to ligand and induce immune peripheral...

article

Effects of adenovirus‐induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model

Sina Fuchs, Monika Bayer, Richard Taubert, Michael P. Manns, more

Liver International > 39 > 12 > 2330 - 2340

Background & Aims Four major autoimmune diseases target the liver. They develop because of bile duct destruction, leading to chronic cholestasis or result from hepatocyte damage like autoimmune hepatitis (AIH). Interestingly, some patients simultaneously show features of both cholangitis and AIH. Our goal was to mimic such concurrent characteristics in a mouse model that would help deciphering...

article

Position statement on access to care in rare liver diseases: advancements of the European reference network (ERN) RARE-LIVER

Lucas H. P. Bernts, David E. J. Jones, Marleen M. Kaatee, Ansgar W. Lohse, more

Orphanet Journal of Rare Diseases > 2019 > 14 > 1 > 1-8

The European Reference Network for rare liver diseases (ERN RARE-LIVER) is a Europe-wide network of paediatric and adult hepatologists from expert centres in close collaboration with patient advocates from the various disease-areas covered in our ERN. The ERN is focused on providing more equitable care across Europe and creates a network of both medical specialists and patient experts in rare liver...

article

A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins

Wei Zhang, Jung-hyun Rho, Michael H. Roehrl, Julia Y. Wang

BMC Immunology > 2019 > 20 > 1 > 1-14

Background Autoimmune diseases result from aberrant immune attacks by the body itself. It is mysterious how autoantigens, a large cohort of seemingly unconnected molecules expressed in different parts of the body, can induce similar autoimmune responses. We have previously found that dermatan sulfate (DS) can form complexes with molecules of apoptotic cells and stimulate autoreactive CD5+ B cells...

article

CD4⁺ T cells from patients with primary biliary cholangitis show T cell activation and differentially expressed T‐cell receptor repertoires

Ryo Nakagawa, Ryosuke Muroyama, Chisato Saeki, Tsunekazu Oikawa, more

Hepatology Research > 49 > 6 > 653 - 662

Aim Primary biliary cholangitis (PBC) is an autoimmune liver disease with unknown pathogenesis. In PBC, activation of T‐cell receptor (TCR) signaling is associated with inflammatory cytokine production through N‐Ras upregulation. Although the CD4⁺ T cell TCR repertoire could be associated with PBC pathogenesis, it has not been evaluated. Thus, we analyzed the PBC‐CD4⁺ T cell TCR repertoire using...

article

Cirrhosis and Autoimmune Liver Disease

Guido Stirnimann, Maryam Ebadi, Andrew L. Mason, Aldo J. Montano-Loza

Current Hepatology Reports > 2019 > 18 > 1 > 49-58

Purpose of Review Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) constitute the most frequently observed forms of autoimmune liver diseases. Each of these autoimmune liver diseases might present with cirrhosis at diagnosis, and a significant proportion of patients develop cirrhosis during follow-up. This manuscript provides a review that addresses...

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Search results

Safety and effectiveness of SARS‐CoV‐2 vaccines for patients with intractable hepatobiliary diseases: A multicenter, questionnaire‐based, cross‐sectional study

Correlation between hepatic venous pressure gradient and portal pressure gradient in patients with autoimmune cirrhotic portal hypertension and collateral branches of the hepatic vein

Liver abnormalities in celiac disease and response to gluten free diet: A systematic review and meta‐analysis

Metabolomics‐based researches in autoimmune liver disease: A mini‐review

Next‐generation sequencing in the evaluation of biliary strictures in patients with primary sclerosing cholangitis

Machine learning in primary biliary cholangitis: A novel approach for risk stratification

Psychiatric comorbidity in childhood onset immune‐mediated diseases—A systematic review and meta‐analysis

Sarcopenia is highly prevalent in children with autoimmune liver diseases and is linked to visceral fat and parent‐perceived general health

Rates of decompensation, hepatocellular carcinoma and mortality in AMA‐negative primary biliary cholangitis cirrhosis

Epstein–Barr virus status and immunosuppression use in paediatric autoimmune liver disease

Bone microarchitecture in patients with autoimmune hepatitis

A nomogram based on pretreatment clinical parameters for the prediction of inadequate biochemical response in primary biliary cholangitis

Gut dysbiosis associated with clinical prognosis of patients with primary biliary cholangitis

Increasing prevalence of primary biliary cholangitis in Victoria, Australia

TIM‐3: An emerging target in the liver diseases

Effects of adenovirus‐induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model

Position statement on access to care in rare liver diseases: advancements of the European reference network (ERN) RARE-LIVER

A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins

CD4⁺ T cells from patients with primary biliary cholangitis show T cell activation and differentially expressed T‐cell receptor repertoires

Cirrhosis and Autoimmune Liver Disease

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