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This investigation seeks to identify the effects of the EtOAc fractions of different flower parts of Paeonia decomposita (Pd) and Paeonia ostii (Po) on melanogenesis and their mechanisms of action in B16 melanoma cells. Cell viability assay showed that Pd‐1, Po‐1 (the petals of Pd or Po), Pd‐3 and Po‐3 (the stamens of Pd or Po) at 25 μg/ml produced lower toxic activities in B16 cells. Pd‐1 and Po‐1...