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BackgroundWe have previously shown that aerosol interleukin‐2 (IL‐2) increased the number of intravenously injected human natural killer (NK) cells in the lungs. In this study we investigated whether this increase was secondary to NK cell proliferation and determined the site of the proliferation.
Materials and MethodsNude mice with osteosarcoma lung metastases were injected with NK cells and treated...
BackgroundSurvival of patients with osteosarcoma lung metastases has not improved in 20 years. We evaluated the efficacy of combining natural killer (NK) cells with aerosol interleukin‐2 (IL‐2) to achieve organ‐specific NK cell migration and expansion in the metastatic organ, and to decrease toxicity associated with systemic IL‐2.
ProcedureFive human osteosarcoma cell lines and 103 patient samples...
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