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Motivated by the recent acquired immune deficiency syndrome clinical trial study A5175, we propose a semiparametric framework to describe time‐to‐event data, where only the dependence of the mean and variance of the time on the covariates are specified through a restricted moment model. We use a second‐order semiparametric efficient score combined with a non‐parametric imputation device for estimation...
Factorial trials are an efficient method of assessing multiple treatments in a single trial, saving both time and resources. However, they rely on the assumption of no interaction between treatment arms. Ignoring the possibility of an interaction in the analysis can lead to bias and potentially misleading conclusions. Therefore, it is often recommended that the size of the interaction be assessed...
Plant breeders and variety testing agencies routinely test candidate genotypes (crop varieties, lines, test hybrids) in multiple environments. Such multi‐environment trials can be efficiently analysed by mixed models. A single‐stage analysis models the entire observed data at the level of individual plots. This kind of analysis is usually considered as the gold standard. In practice, however, it is...
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