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H + -F O F 1 -ATP synthase couples proton flow through its membrane portion, F O , to the synthesis of ATP in its headpiece, F 1 . Upon reversal of the reaction the enzyme functions as a proton pumping ATPase. Even in the simplest bacterial enzyme the ATPase activity is regulated by several mechanisms, involving inhibition by MgADP, conformational transitions...
Background: T-cell receptor γ (TCR-γ) is involved in maintaining host cell integrity and homeostasis of the human immune system. We hypothesize that polymorphism of the TCR-γ complex may be involved in the pathogenesis of colorectal cancer. Methods: The microsatellite markers D7S1818 and D7S2206 located within the TCR-γ antigen locus on chromosome 7p were amplified by polymerase chain reaction,...
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