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Items from 1 to 20 out of 231 results

article

Risk factors for the long‐term persistent genitourinary toxicity after stereotactic body radiation therapy for localized prostate cancer: A single‐center, retrospective study of 306 patients

Kenji Tanabe, Shuichiro Kobayashi, Takashi Tamiya, Tsuzumi Konishi, more

International Journal of Urology > 31 > 9 > 1022 - 1029

Objectives To identify risk factors for the long‐term persistent genitourinary toxicity (GUT) after stereotactic body radiation therapy (SBRT) for localized prostate cancer (PCa). Methods A total of 306 patients who underwent SBRT at our institution between March 2017 and April 2022 were retrospectively evaluated. SBRT was performed at 35 Gy in five fractions over 5 or 10 days. Factors related...

article

Dynamic liver volume change in predicting hepatic decompensation and long‐term effects of stereotactic body radiation therapy

Sumin Lee, Jonggi Choi, Jin‐hong Park, Chae Yeon Lim, more

Journal of Gastroenterology and Hepatology > 39 > 8 > 1648 - 1655

Background and Aim This study aimed to investigate the association between liver volume change and hepatic decompensation and compare the risk of hepatic decompensation in patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) who underwent stereotactic body radiation therapy (SBRT). Methods A retrospective review of SBRT‐treated HCC and compensated LC without HCC patients was conducted...

article

Longitudinal quality of life after sublobar resection and stereotactic body radiation therapy for early‐stage non–small cell lung cancer

Juan P. Wisnivesky, Jeremy Mudd, Kimberly Stone, Christopher G. Slatore, more

Cancer > 130 > 14 > 2515 - 2527

Background Many patients with early‐stage lung cancer are not candidates for lobectomy because of various factors, with treatment options including sublobar resection or stereotactic body radiation therapy (SBRT). Limited information exists regarding patient‐centered outcomes after these treatments. Methods Subjects with stage I–IIA non–small cell lung cancer (NSCLC) at high risk for lobectomy...

article

Role of stereotactic body radiotherapy for inferior vena cava tumour thrombus in hepatocellular carcinoma

Deepti Sharma, Deepak Thaper, Rose Kamal, Hanuman Prasad Yadav

Journal of Medical Imaging and Radiation Oncology > 67 > 4 > 444 - 449

Introduction To evaluate the role of stereotactic body radiotherapy (SBRT) in hepatocellular carcinoma (HCC) patients with inferior vena cava tumour thrombus (IVCTT) who are not suitable for other loco‐regional therapies. Methods This is an observational retrospective study done between May 2020 and April 2022. The data of 17 patients who underwent SBRT were collected. Patients of Child–Pugh score...

article

LUNAR: a randomized Phase 2 study of ¹⁷⁷Lutetium‐PSMA Neoadjuvant to Ablative Radiotherapy for Oligorecurrent Prostate Cancer (clinical trial protocol)

Ting Martin Ma, Johannes Czernin, Carol Felix, Rejah Alano, more

BJU International > 132 > 1 > 65 - 74

Objective To assess the efficacy of ¹⁷⁷Lu‐PNT2002, a novel radiolabelled small molecule that binds with high affinity to prostate‐specific membrane antigen (PSMA), in combination with stereotactic body radiotherapy (SBRT) to all sites of metastasis, vs SBRT alone, in men with oligorecurrent metastatic hormone‐sensitive prostate cancer (mHSPC). Patients and Methods The ¹⁷⁷Lutetium‐PSMA Neoadjuvant...

article

Potential benefit of dose‐escalated stereotactic body radiation therapy using CyberKnife for early‐stage primary lung cancer

Shou Watanabe, Hideya Yamazaki, Takuya Kimoto, Hiroya Shiomi, more

Asia‐Pacific Journal of Clinical Oncology > 19 > 3 > 320 - 326

Introduction The study aimed to evaluate the efficacy and safety of dose‐escalated stereotactic body radiotherapy (SBRT) for primary lung cancer. Methods Patients with peripherally located T1‐2N0M0 primary lung cancer who underwent SBRT from April 2013 to December 2019 were included. Group A received 60 Gy in five fractions with CyberKnife prescribed at 99% gross tumor volume. Group B received...

article

Salvage stereotactic body radiation therapy for locally recurrent prostate cancer following primary radiation therapy, are benefits worth toxicity risks?: A systematic review

Gerard Bray, Arya Bahadori, Darren Rama

The Prostate > 83 > 6 > 489 - 497

Introduction Salvage stereotactic body radiation therapy (SBRT) for localized prostate cancer recurrence following radiation therapy remains controversial. We performed a systematic review to assess the efficacy and side effect profile of salvage SBRT for locally recurrent prostate cancer to define the role of salvage SBRT in clinical practice. Methods A systematic review was carried out using...

article

Patient outcomes following implementation of an enhanced recovery after surgery pathway for patients with metastatic spine tumors

Vikram B. Chakravarthy, Ilya Laufer, Anubhav G. Amin, Marc A. Cohen, more

Cancer > 128 > 23 > 4109 - 4118

Background Metastatic spine tumor surgery consists of palliative operations performed on frail patients with multiple medical comorbidities. Enhanced recovery after surgery (ERAS) programs involve an evidence‐based, multidisciplinary approach to improve perioperative outcomes. This study presents clinical outcomes of a metastatic spine tumor ERAS pathway implemented at a tertiary cancer center. ...

article

Better preservation of erectile function in localized prostate cancer patients with modern proton therapy: Is it cost‐effective?

Guo Li, Yun‐Fei Xia, Yi‐Xiang Huang, Deniz Okat, more

The Prostate > 82 > 15 > 1438 - 1446

Background Stereotactic body radiation therapy (SBRT) has gradually been recognized as favorable curative treatment for localized prostate cancer (PC). However, the high rate of erectile dysfunction (ED) after traditional photon‐based SBRT remains an ongoing challenge that greatly impacts the quality of life of PC survivors. Modern proton therapy allows higher conformal SBRT delivery and has the...

article

Fifty‐year history of the evolution of spinal metastatic disease management

W. Christopher Newman, Mark H. Bilsky

Journal of Surgical Oncology > 126 > 5 > 913 - 920

Spine metastases are a significant source of morbidity in oncology. Treatment of these spine metastases largely remains palliative, but advances over the past 50 years have improved the effectiveness of interventions for preserving functional status and obtaining local control while minimizing morbidity. While the field began with conventional external beam radiation as the primary treatment modality,...

article

Comparative study of the collapsed cone convolution and Monte Carlo algorithms for radiation therapy planning of canine sinonasal tumors reveals significant dosimetric differences

Ber‐In Lee, Mary‐Keara Boss, Susan M. LaRue, Tiffany Martin, more

Veterinary Radiology & Ultrasound > 63 > 1 > 91 - 101

Computer‐based radiation therapy requires high targeting and dosimetric precision. Analytical dosimetric algorithms typically are fast and clinically viable but can have increasing errors near air‐bone interfaces. These are commonly found within dogs undergoing radiation planning for sinonasal cancer. This retrospective methods comparison study is designed to compare the dosimetry of both tumor volumes...

article

Radiofrequency ablation versus stereotactic body radiation therapy for small (≤ 3 cm) hepatocellular carcinoma: A retrospective comparison analysis

Yuri Jeong, Kyung Jin Lee, So Jung Lee, Yong Moon Shin, more

Journal of Gastroenterology and Hepatology > 36 > 7 > 1962 - 1970

Background and Aim We compared the clinical outcomes of radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT) in small (≤ 3 cm) hepatocellular carcinoma. Methods A total of 266 patients treated with RFA (n = 179) or SBRT (n = 87) were reviewed. Local control rates (LCRs), intrahepatic recurrence‐free survival (IHRFS) rates, and overall survival (OS) rates were compared. Inverse...

article

Endobronchial coil spring fiducial markers for CyberKnife® stereotactic body radiation therapy

Alessio Casutt, Leslie Noirez, Maurizio Bernasconi, Angela Koutsokera, more

Respirology > 26 > 5 > 469 - 476

Background and objective SBRT is an alternative treatment for early‐stage inoperable lung cancer. Metallic FM allow to increase tumour tracking precision by CyberKnife®. Currently used techniques for FM placement have many limitations; transthoracic insertion has a high risk for pneumothorax, endovascular insertion requires expertise and dedicated angiography infrastructure and endobronchial linear‐gold...

article

Multi‐institutional analysis of stereotactic body radiotherapy for sarcoma pulmonary metastases: High rates of local control with favorable toxicity

Brian C. Baumann, Karen De Amorim Bernstein, Thomas F. DeLaney, Charles B. Simone, more

Journal of Surgical Oncology > 122 > 5 > 877 - 883

Background/Objectives Oligometastatic sarcoma pulmonary metastases (PM's) are traditionally treated with resection and/or chemotherapy. We hypothesize that stereotactic body radiotherapy (SBRT) is an effective, safe alternative to surgery that can achieve excellent local control (LC) with a favorable toxicity profile. Methods Patients treated with SBRT for sarcoma PM's from 2011 to 2016 at Massachusetts...

article

Stereotactic body radiotherapy for medically unfit patients with cancers to the head and neck

Hossam Al‐Assaf, Darby Erler, Irene Karam, Justin W. Lee, more

Head & Neck > 42 > 8 > 2050 - 2057

Background A single institutional experience of stereotactic body radiation therapy (SBRT) to medically unfit patients with unresectable head and neck cancers (HNCs). Methods A retrospective review of HNC patients undergoing SBRT was undertaken from 2011 to 2016 for fractionation ranges between 35 and 50 Gy in 4 to 6 fractions. Results One hundred and fourteen patients with 117 SBRT courses were...

article

Factors affecting target motion in stereotactic body radiotherapy of liver cancer using CyberKnife

Kevin MY Lo, Vincent WC Wu, Yu Li, Hui Jun Xu

Journal of Medical Imaging and Radiation Oncology > 64 > 3 > 408 - 413

Introduction In stereotactic body radiation therapy (SBRT) of solitary liver cancer, organ motion due to respiration is an important factor in the definition of planning target volume (PTV). This study evaluated the potential associations of target motion with gross tumour volume (GTV) size, tumour location, Child–Pugh score and intra‐fraction treatment time in SBRT of liver cancer treated by CyberKnife...

article

Safety and efficacy of fiducial marker implantation for robotic stereotactic body radiation therapy with fiducial tracking

Nathaniel Scher, Marc Bollet, Gauthier Bouilhol, Remi Tannouri, more

Radiation Oncology > 2019 > 14 > 1 > 1-8

Purpose The purpose of this study was to assess the feasibility, efficacy and toxicity of fiducial marker implantation and tracking in CyberKnife® stereotactic radiation therapy (SBRT) applied to extracranial locations. Materials and method This is a retrospective, single-centre, observational study to collect the data of all patients treated by stereotactic radiation therapy with fiducial marker...

article

Biologically effective dose (BED) of stereotactic body radiation therapy (SBRT) was an important factor of therapeutic efficacy in patients with hepatocellular carcinoma (≤5 cm)

Jing Sun, Tao Zhang, Jia Wang, Wengang Li, more

BMC Cancer > 2019 > 19 > 1 > 1-10

Background To explore the association between biologically effective dose (BED) and survival rates in Child-Pugh A classification (CP-A) small hepatocellular carcinoma (HCC) patients treated with stereotactic body radiation therapy (SBRT). Methods This retrospective study included 108 small HCC patients who were treated with SBRT between 2011 and 2014. The prescribed dose delivered to the tumor...

article

Predictive factors for survival outcomes of oligometastatic prostate cancer patients treated with metastases-directed therapy: a recursive partitioning-based analysis

Ciro Franzese, Lucia Brina, Giuseppe D’Agostino, Davide Franceschini, more

Journal of Cancer Research and Clinical Oncology > 2019 > 145 > 10 > 2469-2479

Purpose The aim of the present study was to provide predictive factors for survival outcomes of oligometastatic prostate cancer (PC) patients treated with stereotactic body radiation therapy (SBRT) as a metastases-directed therapy (MDT). Methods In this cohort study, endpoints included overall survival (OS), progression-free survival (PFS), distant progression-free survival (DFS) and local control...

article

Hypofractionated proton beam therapy for centrally located lung cancer

Naoki Nakamura, Kenji Hotta, Sadamoto Zenda, Hiromi Baba, more

Journal of Medical Imaging and Radiation Oncology > 63 > 4 > 552 - 556

Introduction To clarify the efficacy and safety of hypofractionated proton beam therapy (PBT) for centrally located lung cancer. Methods We retrospectively reviewed 39 patients who received hypofractionated [≧3 Gy (relative biological effectiveness: RBE)/fraction] PBT for centrally located cT1‐2N0M0 (8th edition) lung cancer between 1999 and 2015. A tumour within 2 cm of the proximal bronchial...

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Risk factors for the long‐term persistent genitourinary toxicity after stereotactic body radiation therapy for localized prostate cancer: A single‐center, retrospective study of 306 patients

Dynamic liver volume change in predicting hepatic decompensation and long‐term effects of stereotactic body radiation therapy

Longitudinal quality of life after sublobar resection and stereotactic body radiation therapy for early‐stage non–small cell lung cancer

Role of stereotactic body radiotherapy for inferior vena cava tumour thrombus in hepatocellular carcinoma

LUNAR: a randomized Phase 2 study of ¹⁷⁷Lutetium‐PSMA Neoadjuvant to Ablative Radiotherapy for Oligorecurrent Prostate Cancer (clinical trial protocol)

Potential benefit of dose‐escalated stereotactic body radiation therapy using CyberKnife for early‐stage primary lung cancer

Salvage stereotactic body radiation therapy for locally recurrent prostate cancer following primary radiation therapy, are benefits worth toxicity risks?: A systematic review

Patient outcomes following implementation of an enhanced recovery after surgery pathway for patients with metastatic spine tumors

Better preservation of erectile function in localized prostate cancer patients with modern proton therapy: Is it cost‐effective?

Fifty‐year history of the evolution of spinal metastatic disease management

Comparative study of the collapsed cone convolution and Monte Carlo algorithms for radiation therapy planning of canine sinonasal tumors reveals significant dosimetric differences

Radiofrequency ablation versus stereotactic body radiation therapy for small (≤ 3 cm) hepatocellular carcinoma: A retrospective comparison analysis

Endobronchial coil spring fiducial markers for CyberKnife® stereotactic body radiation therapy

Multi‐institutional analysis of stereotactic body radiotherapy for sarcoma pulmonary metastases: High rates of local control with favorable toxicity

Stereotactic body radiotherapy for medically unfit patients with cancers to the head and neck

Factors affecting target motion in stereotactic body radiotherapy of liver cancer using CyberKnife

Safety and efficacy of fiducial marker implantation for robotic stereotactic body radiation therapy with fiducial tracking

Biologically effective dose (BED) of stereotactic body radiation therapy (SBRT) was an important factor of therapeutic efficacy in patients with hepatocellular carcinoma (≤5 cm)

Predictive factors for survival outcomes of oligometastatic prostate cancer patients treated with metastases-directed therapy: a recursive partitioning-based analysis

Hypofractionated proton beam therapy for centrally located lung cancer

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