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Oxaliplatin, a third-generation diaminocyclohexane platinum drug, is widely used alone or in combination with 5-fluorouracil and leucovorin to treat metastatic colorectal, ovarian, and pancreatic cancers. Oxaliplatin long-term treatment is associated with the development of a dose-limiting painful neuropathy that dramatically impairs the patient’s quality of life and therapy possibility.To study novel...
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in fast synaptic transmission. nAChRs are pentameric receptors formed from a combination of different or similar subunits to produce heteromeric or homomeric channels. The heteromeric, α9α10 nAChR subtype is well-known for its role in the auditory system, being expressed in cochlear hair cells. These nAChRs have also...
In this paper, a two-stage method for identification of the sandwich systems with hysteresis is proposed. In the first stage of this method, a monotonic and independently incremental signal is used to degenerate the hysteresis into a static function with one-to-one mapping. Thus, the sandwich system with hysteresis can be transformed into a system described by the combination of the transformed variables...
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