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Objective To study the biochemical changes in the early development of primary guinea-pig knee osteoarthritis (OA) and its dependence on load.Methods Load distribution was modified with below-knee amputation or femur valgus osteotomy in 9-month-old guinea-pigs. Soft tissue sham operated animals served as controls. The composition of uncalcified and calcified articular cartilage at the medial and lateral...