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article

Transplantatvaskulopathie nach Herztransplantation

Annika Kuckhahn, Martina Ramsperger-Gleixner, Stephan Ensminger, Michael Weyand, more

Zeitschrift für Herz-,Thorax- und Gefäßchirurgie > 2019 > 33 > 4 > 293-300

Die chronische Abstoßung mit dem charakteristischen Merkmal der Transplantatvaskulopathie („cardiac allograft vasculopathy“, CAV) ist eine der Hauptkomplikationen nach erfolgreicher Herztransplantation und kann nicht mithilfe derzeit üblicher Immunsuppressiva verhindert werden. In der vorliegenden Übersichtsarbeit wird zunächst die Epidemiologie der CAV beschrieben. Des Weiteren wird detailliert auf...

article

Pathophysiologie der arteriellen Gefäßerkrankung und neue Therapieansätze

T. Deuse

Zeitschrift für Herz-,Thorax- und Gefäßchirurgie > 2015 > 29 > 5 > 335-341

Arterielle Gefäßerkrankungen bedingen u. a. Karotisstenosen, die periphere arterielle Verschlusskrankheit sowie die koronare Herzerkrankung und bilden die häufigste Todesursache der westlichen Welt. Es gibt unterschiedliche Erscheinungsformen, histomorphologische Strukturen, Ätiologien, Risikofaktoren und Komplikationen in diesem Krankheitsgebiet. Obwohl verschiedene Erkrankungen definiert sind, ist...

article

Medikamentenbeschichtete Ballonkatheter in der Behandlung der peripheren arteriellen Verschlusskrankheit

M. Herten, S. Stahlhoff, T. Bisdas, K. Donas, more

Gefässchirurgie > 2013 > 18 > 6 > 520-532

Hintergrund Trotz initial guter Erfolge nach Angioplastie bei peripherer arterieller Verschlusskrankheit (pAVK) bilden Restenosen das Hauptproblem. Sie werden durch neointimale Hyperplasie verursacht und können mithilfe antiproliferativer Substanzen effektiv unterdrückt werden. Zur längerfristigen Hemmung werden medikamentenbeschichtete Ballonkatheter („drug-coated balloon“, DCB) und -“drug-coated...

article

Angioscopic Findings after Drug-Eluting Stent Implantation

Masamichi Takano, Kyoichi Mizuno

Herz > 2007 > 32 > 4 > 281-286

In-stent restenosis is the Achilles' heel of standard or bare-metal stent (BMS) implantation, occurring in 10–40% of the patients. Drug-eluting stent (DES) are supposed to inhibit inflammation and neointimal growth and, subsequently, in-stent restenosis. The neointimal proliferation inside the stent is recognized as lumen late loss on angiograms or as an obstruction area (or volume) on intravascular...

article

Neointimale Hyperplasie durch luminale Zellrekrutierung und nicht durch transmurale Migration

A. Jabs, S. Krämer, D. Skowasch, U. Welsch, more

Clinical Research in Cardiology > 2002 > 91 > 8 > 626-636

Die Restenose bleibt die wesentliche Limitierung verschiedener interventioneller Therapiemassnahmen, auch der Stentimplantation. Dies erklärt das unverändert große Interesse an ihren zugrundeliegenden Pathogenesemechanismen und -faktoren. Ziel der vorliegenden Arbeit war es, Lokalisation und Expressionsmaxima von Bcl-2, einem zentralen anti-apoptotischen Protoonkogen, und von Hitzeschockprotein 47...

article

Sulfamethizole attenuates poloxamer 407‐induced atherosclerotic neointima formation via inhibition of mTOR in C57BL/6 mice

Ankita Solanki, Shreya R. Savla, Maheshkumar R. Borkar, Lokesh K. Bhatt

Journal of Biochemical and Molecular Toxicology > 37 > 5 > n/a - n/a

Mammalian target of Rapamycin C1 (mTORC1) inhibition limits plaque progression in atherosclerosis. The present study evaluated the protective effect of sulfamethizole on poloxamer 407‐induced atherosclerotic neointima formation in C57BL/6 mice via mTOR inhibition. Poloxamer 407 (P‐407) (0.5 g/kg body weight) was administered intraperitoneally to male C57BL/6 mice every third day for 148 days to induce...

article

Clinical implication of neointimal burden in in‐stent restenosis treated with drug‐coated balloon

Jung‐Hee Lee, Ung Kim, Jung‐Sun Kim, Sung‐Jin Hong, more

Catheterization and Cardiovascular Interventions > 98 > 3 > 493 - 502

Background Although drug‐coated balloon (DCB) angioplasty is a well‐established drug‐eluting stent (DES) in‐stent restenosis (ISR) strategy, there are minimal data regarding the association of neointimal burden on optical coherence tomography (OCT) before and after DCB and adverse clinical events. This study aimed to investigate the clinical impact of neointimal burden measured with OCT in patients...

article

miRNA‐200c‐3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts

Dan Chen, Cheng Zhang, Jiangyong Chen, Mei Yang, more

The Journal of Pathology > 253 > 2 > 209 - 224

Increasing evidence has suggested a critical role for endothelial‐to‐mesenchymal transition (EndoMT) in a variety of pathological conditions. MicroRNA‐200c‐3p (miR‐200c‐3p) has been implicated in epithelial‐to‐mesenchymal transition. However, the functional role of miR‐200c‐3p in EndoMT and neointimal hyperplasia in artery bypass grafts remains largely unknown. Here we demonstrated a critical role...

article

S100B is required for maintaining an intermediate state with double-positive Sca-1+ progenitor and vascular smooth muscle cells during neointimal formation

Yan Wu, Xin Liu, Ling-Yun Guo, Lei Zhang, more

Stem Cell Research & Therapy > 2019 > 10 > 1 > 1-16

Introduction Accumulation of vascular smooth muscle cells (VSMCs) within the neointimal region is a hallmark of atherosclerosis and vessel injury. Evidence has shown that Sca-1-positive (Sca-1+) progenitor cells residing in the vascular adventitia play a crucial role in VSMC assemblages and intimal lesions. However, the underlying mechanisms, especially in the circumstances of vascular injury, remain...

article

RECK suppresses interleukin‐17/TRAF3IP2‐mediated MMP‐13 activation and human aortic smooth muscle cell migration and proliferation

Srinivas Mummidi, Nitin A. Das, Andrea J. Carpenter, Tadashi Yoshida, more

Journal of Cellular Physiology > 234 > 12 > 22242 - 22259

Sustained inflammation and matrix metalloproteinase (MMP) activation contribute to vascular occlusive/proliferative disorders. Interleukin‐17 (IL‐17) is a proinflammatory cytokine that signals mainly via TRAF3 Interacting Protein 2 (TRAF3IP2), an upstream regulator of various critical transcription factors, including AP‐1 and NF‐κB. Reversion inducing cysteine rich protein with kazal motifs (RECK)...

article

Inhibitory effects of scoparone from chestnut inner shell on platelet‐derived growth factor‐BB‐induced vascular smooth muscle cell migration and vascular neointima hyperplasia

Seung Hyo Jung, Gyoung Beom Lee, Yunkyoung Ryu, Long Cui, more

Journal of the Science of Food and Agriculture > 99 > 9 > 4397 - 4406

BACKGROUND Compounds of the inner shell of chestnut (Castanea crenata) have diverse biological activities, including anti‐cancer and anti‐oxidant activities. Here we explored the effects of an extract of chestnut inner shells and of its bioactive component scoparone on vascular smooth muscle cell migration and vessel damage. RESULTS The ethanol extract of chestnut inner shells, containing 11 major...

article

Microbubble contrast enhancement of neointima after drug-eluting stent implantation: an optical coherence tomography study

Norikiyo Oka, Tadayuki Kadohira, Kenichi Fujii, Hideki Kitahara, more

Heart and Vessels > 2019 > 34 > 3 > 393-400

Microvessels within neoatherosclerosis are associated with vulnerability and increase from the early to the very late phase after drug-eluting stent implantation. Microbubble contrast agents have been suggested to enhance tissue microvasculature for optical coherence tomography (OCT) imaging. The present study investigated whether OCT signal intensity of neointima within stented segments was enhanced...

article

Carotid artery ligation induced intimal thickening and proliferation is unaffected by ageing

B. A. Brown, H. Williams, A. R. Bond, G. D. Angelini, more

Journal of Cell Communication and Signaling > 2018 > 12 > 3 > 529-537

Following interventions to treat atherosclerosis, such as coronary artery bypass graft surgery, restenosis occurs in approximately 40% of patients. Identification of proteins regulating intimal thickening could represent targets to prevent restenosis. Our group previously demonstrated that in a murine model of vascular occlusion, Wnt4 protein expression and β-catenin signalling was upregulated which...

article

Effects of angiotensin receptor blockers on neointimal characteristics in angina patients requiring stent implantation: optical coherence tomography analysis

Jae Young Cho, Soon Jun Hong, Do-Sun Lim

BMC Cardiovascular Disorders > 2017 > 17 > 1 > 1-8

Background Angiotensin receptor blockers (ARBs) are known for its anti-inflammatory and anti-proliferative effects. The aim of the study was to evaluate long-term effects of ARBs on morphologic characteristics of stent restenosis in patients with coronary artery disease requiring stent implantation by optical coherence tomography (OCT). Methods Patients with coronary artery disease having history...

article

The microRNA miR‐124 inhibits vascular smooth muscle cell proliferation by targeting S100 calcium‐binding protein A4 (S100A4)

Nakwon Choe, Duk‐Hwa Kwon, Sera Shin, Yong Sook Kim, more

FEBS Letters > 591 > 7 > 1041 - 1052

S100 calcium‐binding protein A4 (S100A4) induces proliferation and migration of vascular smooth muscle cells (VSMCs). We aimed to find the microRNA regulating S100A4 expression. S100A4 transcripts are abruptly increased in the acute phase of carotid arterial injury 1 day later (at day 1) but gradually decreases at days 7 and 14. Bioinformatics analysis reveals that miR‐124 targets S100A4. VSMC survival...

article

Recombinant soluble apyrase APT102 inhibits thrombosis and intimal hyperplasia in vein grafts without adversely affecting hemostasis or re‐endothelialization

Y. Ji, O. Adeola, T. L. Strawn, S. S. Jeong, more

Journal of Thrombosis and Haemostasis > 15 > 4 > 814 - 825

Summary Background Occlusion of vein grafts (VGs) after bypass surgery, owing to thrombosis and intimal hyperplasia (IH), is a major clinical problem. Apyrases are enzymes that scavenge extracellular ATP and ADP, and promote adenosine formation at sites of vascular injury, and hence have the potential to inhibit VG pathology. Objectives To examine the effects of recombinant soluble human...

article

High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis

June Guo, Troy J. Pereira, Prasad Dalvi, Lucy Shu Nga Yeung, more

Metabolism > 2017 > 68 > C > 108-118

Our laboratory has shown that insulin's effect to decrease neointimal thickness after arterial injury is greatly diminished in insulin resistant conditions. Thus, in these conditions, a better alternative to insulin could be to use an insulin sensitizing agent. Metformin, the most commonly prescribed insulin sensitizer, has a cardiovascular protective role. Therefore, the objective of this study was...

article

Spatiotemporal mapping of matrix remodelling and evidence of in situ elastogenesis in experimental abdominal aortic aneurysms

Partha Pratim Deb, Anand Ramamurthi

Journal of Tissue Engineering and Regenerative Medicine > 11 > 1 > 231 - 245

Spatiotemporal changes in the extracellular matrix (ECM) were studied within abdominal aortic aneurysms (AAAs) generated in rats via elastase infusion. At 7, 14 and 21 days post‐induction, AAA tissues were divided into proximal, mid‐ and distal regions, based on their location relative to the renal arteries and the region of maximal aortic diameter. Wall thicknesses differed significantly between...

article

Factor VII‐activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation

J.‐M. Daniel, C. A. Reichel, T. Schmidt‐Woell, J. Dutzmann, more

Journal of Thrombosis and Haemostasis > 14 > 10 > 2058 - 2067

Summary Background Factor VII‐activating protease (FSAP) is a multifunctional circulating plasma serine protease involved in thrombosis and vascular remodeling processes. The Marburg I single‐nucleotide polymorphism (MI‐SNP) in the FSAP‐coding gene is characterized by low proteolytic activity, and is associated with increased rates of stroke and carotid stenosis in humans. Objectives To determine...

article

CCL5 deficiency reduces neointima formation following arterial injury and thrombosis in apolipoprotein E-deficient mice

Frauke S. Czepluch, Julia Meier, Claudia Binder, Gerd Hasenfuss, more

Thrombosis Research > 2016 > 144 > C > 136-143

Activated platelets secrete different chemokines, among others CCL5, thereby triggering inflammatory cell recruitment into the vessel wall. Here, we investigated how CCL5 deficiency influences vascular remodeling processes. Experiments were performed in apolipoprotein E and CCL5 double deficient (ApoE^−/−×CCL5^−/−) mice, using ApoE^−/−×CCL5^+/+ mice as controls. The ferric chloride model was applied to...

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NEOINTIMA (217)
RESTENOSIS (44)
PROLIFERATION (17)
ATHEROSCLEROSIS (16)
STENT (16)
OPTICAL COHERENCE TOMOGRAPHY (15)
INTIMAL HYPERPLASIA (12)
ANGIOPLASTY (11)
IN-STENT RESTENOSIS (10)
SMOOTH MUSCLE CELL (9)
VASCULAR SMOOTH MUSCLE CELL (9)
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REMODELING (8)
VASCULAR SMOOTH MUSCLE CELLS (8)
INTRAVASCULAR ULTRASOUND (7)
MIGRATION (7)
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VASCULAR INJURY (7)
VEIN GRAFT (7)
APOPTOSIS (6)
CELL PROLIFERATION (6)
DRUG-ELUTING STENTS (6)
THROMBUS (6)
BALLOON INJURY (5)
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SMOOTH MUSCLE (5)
VASCULAR SMOOTH MUSCLE (5)
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ENDOTHELIUM (3)
EPTFE (3)
GENE TRANSFER (3)
HYALURONAN (3)
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NF-ΚB (3)
PDGF (3)
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RAT (3)
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SIROLIMUS-ELUTING STENT (3)
STENTS (3)
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VESSEL INJURY (3)
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Search results

Transplantatvaskulopathie nach Herztransplantation

Pathophysiologie der arteriellen Gefäßerkrankung und neue Therapieansätze

Medikamentenbeschichtete Ballonkatheter in der Behandlung der peripheren arteriellen Verschlusskrankheit

Angioscopic Findings after Drug-Eluting Stent Implantation

Neointimale Hyperplasie durch luminale Zellrekrutierung und nicht durch transmurale Migration

Sulfamethizole attenuates poloxamer 407‐induced atherosclerotic neointima formation via inhibition of mTOR in C57BL/6 mice

Clinical implication of neointimal burden in in‐stent restenosis treated with drug‐coated balloon

miRNA‐200c‐3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts

S100B is required for maintaining an intermediate state with double-positive Sca-1+ progenitor and vascular smooth muscle cells during neointimal formation

RECK suppresses interleukin‐17/TRAF3IP2‐mediated MMP‐13 activation and human aortic smooth muscle cell migration and proliferation

Inhibitory effects of scoparone from chestnut inner shell on platelet‐derived growth factor‐BB‐induced vascular smooth muscle cell migration and vascular neointima hyperplasia

Microbubble contrast enhancement of neointima after drug-eluting stent implantation: an optical coherence tomography study

Carotid artery ligation induced intimal thickening and proliferation is unaffected by ageing

Effects of angiotensin receptor blockers on neointimal characteristics in angina patients requiring stent implantation: optical coherence tomography analysis

The microRNA miR‐124 inhibits vascular smooth muscle cell proliferation by targeting S100 calcium‐binding protein A4 (S100A4)

Recombinant soluble apyrase APT102 inhibits thrombosis and intimal hyperplasia in vein grafts without adversely affecting hemostasis or re‐endothelialization

High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis

Spatiotemporal mapping of matrix remodelling and evidence of in situ elastogenesis in experimental abdominal aortic aneurysms

Factor VII‐activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation

CCL5 deficiency reduces neointima formation following arterial injury and thrombosis in apolipoprotein E-deficient mice

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