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A series of novel lipophilic vitamin C derivatives, 6-O-acyl-2-O-α-d-glucopyranosyl-l-ascorbic acids possessing a branched-acyl chain of varying length from C 8 to C 16 (6-bAcyl-AA-2G), were evaluated as topical prodrugs of ascorbic acid (AA) with transdermal activity in a human living skin equivalent model. The permeability of 6-bAcyl-AA-2G was compared with those of the derivatives...