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The role of endothelial nitric oxide (NO) in the cerebrovascular response to partial seizures was investigated in mice deleted for the endothelial NO synthase gene (eNOS−/−) and in their paired wild-type (WT) congeners. Local cerebral blood flow (LCBF, quantitative [ 14 C]iodoantipyrine method) was measured 3–6 h after unilateral kainate (KA) injection in the dorsal hippocampus; controls received...
The role of neuronal nitric oxide (NO) in the cerebrovascular response to partial seizures induced by intrahippocampal injection of kainate (KA) was investigated in mice deleted for the neuronal NO synthase gene (nNOS−/−) and in wild-type controls (WT). A second group of WT mice received the nNOS inhibitor, 7-nitroindazole (WT-7NI). Local cerebral blood flow (LCBF) was measured using the quantitative...
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