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Items from 1 to 20 out of 215 results

article

Granzyme B inhibition reduces autoantibody‐induced dermal–epidermal separation in an ex vivo model of epidermolysis bullosa acquisita

Shirin Emtenani, Hélène Lebhar, Christopher P. Marquis, Ralf J. Ludwig, more

Experimental Dermatology > 33 > 9 > n/a - n/a

The pemphigoid disease epidermolysis bullosa acquisita (EBA) is an autoimmune blistering skin disease characterized by autoantibodies against type VII collagen (COL7), immune cell infiltrates at the dermal–epidermal junction and subepidermal blistering. Proteases, particularly granzyme B (GzmB), have been established as therapeutic targets for the treatment of EBA and other pemphigoid diseases. We...

article

Dual‐Sensing Nanoreporter for Dynamic and High‐Throughput Monitoring of Immune Checkpoint Inhibitor Responses in Tumor‐Derived Organoids

Anh Nguyen, Anujan Ramesh, Adam Fish, Ashish A. Kulkarni

Advanced Functional Materials > 34 > 33 > n/a - n/a

Heterogenous immune responses to checkpoint blockade therapy remain a major challenge to early prediction of treatment efficacy. Current methods of evaluating treatment efficacy in tumors are ineffective in accurately monitoring the disease status after immunotherapy early on. This study reports an immune response monitoring strategy that longitudinally reports on two crucial protease activities involved...

article

Granzyme B promotes matrix metalloproteinase‐1 (MMP‐1) release from gingival fibroblasts in a PAR1‐ and Erk1/2‐dependent manner: A novel role in periodontal inflammation

Mohamed Ben‐Eltriki, Amir Reza Ahmadi, Yuya Nakao, Kalyan Golla, more

Journal of Periodontal Research > 59 > 1 > 94 - 103

Objective To gain insights into how proteases signal to connective tissues cells in the periodontium. Background The connective tissue degradation observed in periodontitis is largely due to matrix metalloproteinase (MMP) release by gingival fibroblasts. Granzyme B (GzmB) is a serine protease whose role in periodontitis is undefined. Methods Human gingival crevicular fluid (GCF) samples were...

article

Imaging and monitoring of granzyme B in the immune response

Xiangxia Li, Guiyuan Chen, Kecheng Wu, Haocheng Zheng, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 16 > 1 > n/a - n/a

Significant progress has been made in tumor immunotherapy that uses the human immune response to kill and remove tumor cells. However, overreactive immune response could lead to various autoimmune diseases and acute rejection. Accurate and specific monitoring of immune responses in these processes could help select appropriate therapies and regimens for the patient and could reduce the risk of side...

article

Limocitrin increases cytotoxicity of KHYG‐1 cells against K562 cells by modulating MAPK pathway

Ming‐Ju Hsieh, Jen‐Tsun Lin, Yi‐Ching Chuang, Chia‐Chieh Lin, more

Environmental Toxicology > 38 > 12 > 2939 - 2951

Natural killer (NK) cells are gaining popularity in the field of cancer immunotherapy. The present study was designed to investigate the effect of a natural flavonol compound limocitrin in increasing cytotoxicity of a permanent NK leukemia cell line KHYG‐1 against an aggressive leukemia cell line K562. The findings revealed that limocitrin increased the expressions of cytolytic molecules perforin,...

article

Synthesis and evaluation of ¹¹¹In‐labeled tetrapeptide‐based compounds as single‐photon emission computed tomography imaging probes targeting granzyme B

Nobuki Kazuta, Hiroyuki Watanabe, Masahiro Ono

Journal of Labelled Compounds and Radiopharmaceuticals > 66 > 10 > 298 - 307

Granzyme B is an attractive target as a biomarker for contributing to improve the treatment with immune checkpoint inhibitor (ICI). In this study, we designed novel ¹¹¹In‐labeled granzyme B‐targeting single‐photon emission computed tomography (SPECT) imaging probes, [¹¹¹In]IDT and [¹¹¹In]IDAT. Nonradioactive In‐labeled granzyme B‐targeting compounds ([^natIn]IDT, [^natIn]IDAT) showed the affinity for...

article

Melanocyte‐specific CD49a⁺CD8⁺ T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy

Kazunori Yokoi, Rei Watanabe, Miki Kume, Saki Yamane, more

The Journal of Dermatology > 50 > 5 > 710 - 714

Vitiligo is a common depigmenting skin disease that is often difficult to treat. Even if repigmentation is achieved by treatment, recurrence in the same lesion is often found within a year after stopping treatment. As a background of these issues, a subset of CD8⁺ T cells that recognize melanocyte‐specific antigens or CD49a⁺ tissue‐resident memory T cells that reside in the vitiligo lesion are thought...

article

Dual roles of granzyme B

Huiling Wang, Yong Huang, Jian He, Liping Zhong, more

Scandinavian Journal of Immunology > 94 > 3 > n/a - n/a

Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on GZMB have gradually revealed the negative extracellular functions of GZMB; for example, it is an aetiology and a factor responsible for the aggravation of several diseases. This review focuses on the positive role of GZMB...

article

Impact of the menstrual cycle and ethinyl estradiol/etonogestrel contraceptive vaginal ring on granulysin and other mucosal immune mediators

Sean M. Hughes, Urvashi Pandey, Christine Johnston, Jeanne Marrazzo, more

American Journal of Reproductive Immunology > 86 > 2 > n/a - n/a

Problem Changes in sex hormones during the menstrual cycle and contraceptive vaginal ring (CVR) use influence immunity within the female genital tract, but the magnitude of these effects and their anatomical location are unclear. Method of Study In a prospective study, 29 women were assessed at three‐time points: follicular phase, luteal phase, and one month after initiation of the ethinyl estradiol/etonogestrel...

article

Identification of CD56^dim subpopulation marked with high expression of GZMB/PRF1/PI‐9 in CD56⁺ interferon‐α‐induced dendritic cells

Asuka Watanabe, Misa Togi, Terutsugu Koya, Makoto Taniguchi, more

Genes to Cells > 26 > 5 > 313 - 327

As the sentinels of innate and adaptive immune system, dendritic cells (DCs) have been considered to hold a great promise for medical application. Among the diverse types of DCs, monocyte‐derived DCs (mo‐DCs) generated in vitro have been most commonly employed. We have been improving the culture protocol and devised a protocol to produce mature interferon‐α‐induced DCs (IFN‐DCs), hereinafter called...

article

Transcriptional meta‐analysis of regulatory B cells

Florian Dubois, Sophie Limou, Mélanie Chesneau, Nicolas Degauque, more

European Journal of Immunology > 50 > 11 > 1757 - 1769

Regulatory B cells (Bregs) have the ability to regulate inflammation in various pathological situations, making them key players in immune regulation. Several mechanisms have been described and we recently identified a GZMB expressing Breg population in kidney transplanted patients who tolerate a kidney graft. To further investigate their biology and mechanisms, we conducted a transcriptomic analysis...

article

Role of Caspases in the Cytotoxicity of NK-92 Cells in Various Models of Coculturing with Trophoblasts

Yu. P. Milyutina, V. A. Mikhailova, K. M. Pyatygina, E. S. Demidova, more

Biochemistry (Moscow) > 2019 > 84 > 10 > 1186-1196

Studies of interactions between natural killer (NK) cells and trophoblasts and identification of conditions for the NK cells to perform their cytotoxic function are of fundamental and practical importance for understanding their role in the development of pathological processes and complications during pregnancy. In this study, we examined changes in the content of caspases and studied activation...

article

Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B

Lawrence H. Cheung, Yunli Zhao, Ana Alvarez-Cienfuegos, Khalid A. Mohamedali, more

Journal of Experimental & Clinical Cancer Research > 2019 > 38 > 1 > 1-14

Background Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting tremendous potential for treatment in a broad spectrum of tumor types. After complex recognition of target cells by T and B cells, delivery of the serine protease granzyme B (GrB) to tumor cells comprises the cytotoxic insult resulting in...

article

Mouse CD8⁺NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells

Zhengyuan Li, Yiqing Wu, Chao Wang, Minghui Zhang

Cancer Immunology, Immunotherapy > 2019 > 68 > 8 > 1303-1315

Our previous work has demonstrated the high efficiency of CD8⁺ natural killer T (NKT)-like cells in killing antigen-bearing dendritic cells. To evaluate their role in the tumor microenvironment, we performed in vitro and in vivo antitumor experiments to investigate whether CD8⁺NKT-like cells could kill Yac-1 and B16 cells like NK cells and kill EL4-OVA8 cells in an antigen-specific manner like cytotoxic...

article

Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Chunwan Lu, John D. Klement, Mohammed L. Ibrahim, Wei Xiao, more

Journal for ImmunoTherapy of Cancer > 2019 > 7 > 1 > 1-11

Background Type I interferons (IFN-I) have recently emerged as key regulators of tumor response to chemotherapy and immunotherapy. However, IFN-I function in cytotoxic T lymphocytes (CTLs) in the tumor microenvironment is largely unknown. Methods Tumor tissues and CTLs of human colorectal cancer patients were analyzed for interferon (alpha and beta) receptor 1 (IFNAR1) expression. IFNAR1 knock out...

article

Anti-inflammatory activity of extensively hydrolyzed casein is mediated by granzyme B

Xuefei Hu, Yan Zhong, Tim T. Lambers, Wenzheng Jiang

Inflammation Research > 2019 > 68 > 8 > 715-722

Objective Nutritional factors such as extensively hydrolyzed casein (eHC) have been proposed to exert anti-inflammatory activity and affect clinical outcomes such as tolerance development in cow’s milk allergy. Granzyme B (GrB) induces apoptosis in target cells and also controls the inflammatory response. Whether eHC could affect the activity of granzyme B and play a role in GrB-mediated inflammatory...

article

Synergistic effect of granzyme B-azurin fusion protein on breast cancer cells

Nafiseh Paydarnia, Shahryar Khoshtinat Nikkhoi, Azita Fakhravar, Mohsen Mehdiabdol, more

Molecular Biology Reports > 2019 > 46 > 3 > 3129-3140

As one of the most prevalent malignancies, breast cancer still remains a significant risk for public health. Common therapeutic strategies include invasive surgery, chemotherapy and anti-herceptin antibodies. Adverse effects, drug resistance and low efficacy of current therapies necessitates the emergence of more effective platforms. Naturally released by the immune system, granzyme B activates multiple...

article

Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70‐Positive Tumors for Multimodal Cancer Theranostics

Maxim Shevtsov, Stefan Stangl, Boris Nikolaev, Ludmila Yakovleva, more

Small > 15 > 13 > n/a - n/a

Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as potential clinical tools for cancer theranostics. Membrane‐bound 70 kDa heat shock protein (mHsp70) is ubiquitously expressed on the cell membrane of various tumor types but not normal cells and therefore provides a tumor‐specific target. The serine protease granzyme B (GrB) that is produced as an effector molecule...

article

Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII‐independent manner

Brandon Stopnicki, Manon Blain, Qiao‐Ling Cui, Timothy E. Kennedy, more

Glia > 67 > 4 > 582 - 593

During inflammatory processes of the central nervous system, helper T cells have the capacity to cross the blood–brain barrier and injure or kill neural cells through cytotoxic mechanisms. Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is part of the astrocyte cytoskeleton that can become fragmented in neuroinflammatory conditions. The mechanism of action by which...

article

Immune signatures for HIV-1 and HIV-2 induced CD4⁺T cell dysregulation in an Indian cohort

Sukeshani Salwe, Amitkumar Singh, Varsha Padwal, Shilpa Velhal, more

BMC Infectious Diseases > 2019 > 19 > 1 > 1-13

Background HIV-2 infection is characterised by a longer asymptomatic phase and slower AIDS progression than HIV-1 infection. Identifying unique immune signatures associated with HIV-2 pathogenesis may thus provide therapeutically useful insight into the management of HIV infection. This study examined the dynamics of the CD4⁺T cell compartment, critical in disease progression, focussing on chronic...

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Search results

Granzyme B inhibition reduces autoantibody‐induced dermal–epidermal separation in an ex vivo model of epidermolysis bullosa acquisita

Dual‐Sensing Nanoreporter for Dynamic and High‐Throughput Monitoring of Immune Checkpoint Inhibitor Responses in Tumor‐Derived Organoids

Granzyme B promotes matrix metalloproteinase‐1 (MMP‐1) release from gingival fibroblasts in a PAR1‐ and Erk1/2‐dependent manner: A novel role in periodontal inflammation

Imaging and monitoring of granzyme B in the immune response

Limocitrin increases cytotoxicity of KHYG‐1 cells against K562 cells by modulating MAPK pathway

Synthesis and evaluation of ¹¹¹In‐labeled tetrapeptide‐based compounds as single‐photon emission computed tomography imaging probes targeting granzyme B

Melanocyte‐specific CD49a⁺CD8⁺ T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy

Dual roles of granzyme B

Impact of the menstrual cycle and ethinyl estradiol/etonogestrel contraceptive vaginal ring on granulysin and other mucosal immune mediators

Identification of CD56^dim subpopulation marked with high expression of GZMB/PRF1/PI‐9 in CD56⁺ interferon‐α‐induced dendritic cells

Transcriptional meta‐analysis of regulatory B cells

Role of Caspases in the Cytotoxicity of NK-92 Cells in Various Models of Coculturing with Trophoblasts

Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B

Mouse CD8⁺NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells

Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Anti-inflammatory activity of extensively hydrolyzed casein is mediated by granzyme B

Synergistic effect of granzyme B-azurin fusion protein on breast cancer cells

Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70‐Positive Tumors for Multimodal Cancer Theranostics

Helper CD4 T cells expressing granzyme B cause glial fibrillary acidic protein fragmentation in astrocytes in an MHCII‐independent manner

Immune signatures for HIV-1 and HIV-2 induced CD4⁺T cell dysregulation in an Indian cohort

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